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Nerve growth factor signaling, neuroprotection, and neural repair.
Expanded roles for NGF that are associated with the dynamically regulated production of NGF and its receptors that begins in development, extends throughout adult life and aging, and involves a surprising variety of neurons, glia, and nonneural cells are considered.
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities.
This model has made possible a step in the genetic dissection of the learning, behavioral, and neurological abnormalities associated with segmental trisomy for the region of mouse chromosome 16 homologous with the so-called "Down syndrome region" of human chromosome segment 21q22.
Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment
This review examines the large body of toxicological and epidemiological information on human exposures to chlorpyrifos, with an emphasis on the controversial potential for chlorpyrifos to induce
Hippocampal Long-Term Potentiation Suppressed by Increased Inhibition in the Ts65Dn Mouse, a Genetic Model of Down Syndrome
Several lines of evidence suggest that inhibition in the Ts65Dn dentate gyrus was enhanced, at least in part, because of presynaptic abnormalities, which raises the possibility that similar changes contribute to abnormalities in learning and memory in people with DS and, perhaps, in other developmental disorders with cognitive failure.
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome.
Findings suggest that Ts65Dn mice may be used to study certain developmental and degenerative abnormalities in the DS brain, including markers of the Alzheimer disease pathology that is present in elderly DS individuals.
NGF Signaling in Sensory Neurons Evidence that Early Endosomes Carry NGF Retrograde Signals
In vivo and in vitro evidence is provided for the presence within DRG neurons of endosomes containing NGF, activated TrkA, and signaling proteins of the Rap1/Erk1/2, p38MAPK, and PI3K/Akt pathways that convey NGF signals from the target of nociceptive neurons to their cell bodies.
Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes
Examination of early events in the membrane traffic of NGF and its receptor, gp140TrkA, in PC12 cells raises the possibility that NGF induces formation of signaling endosomes containing activated TrkA and binds to these receptors were competent to initiate signal transduction.
Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion
The findings are evidence that even BFCNs chronically deprived of endogenous NGF respond to an intervention that compensates for defective retrograde transport, and suggest that age-related cholinergic neurodegeneration may be a treatable disorder of failed retrograde NGF signaling.
One at a time, live tracking of NGF axonal transport using quantum dots
  • B. Cui, C. Wu, +5 authors S. Chu
  • Biology, Medicine
    Proceedings of the National Academy of Sciences
  • 21 August 2007
These findings point to the possibility that a single NGF dimer is sufficient to sustain signaling during retrograde axonal transport to the cell body, and suggest that NGF signal propagation through the axon terminal is regulated by a single molecule.
Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment.
The results of this review demonstrate that the use of urinary 3,5,6-trichlorpyridinol (TCPy), a metabolite of chlorpyrifos as a biomarker of nonoccupational exposure is problematic and may overestimate non Occupational exposures to chlorparyifos by 10-to 20-fold because of the widespread presence of both TCPy and chlorp Pyrifos-methyl in the food supply.