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Phi29 family of phages.
Continuous research spanning more than three decades has made the Bacillus bacteriophage phi29 a paradigm for several molecular mechanisms of general biological processes, such as DNA replication,Expand
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Spo0A, the key transcriptional regulator for entrance into sporulation, is an inhibitor of DNA replication
The transcription factor Spo0A is a master regulator for entry into sporulation in Bacillus subtilis and also regulates expression of the virulent B. subtilis phage ϕ29. Here, we describe a novelExpand
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Mobility of the Native Bacillus subtilis Conjugative Plasmid pLS20 Is Regulated by Intercellular Signaling
Horizontal gene transfer mediated by plasmid conjugation plays a significant role in the evolution of bacterial species, as well as in the dissemination of antibiotic resistance and pathogenicityExpand
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φ29 Family of Phages
SUMMARY Continuous research spanning more than three decades has made the Bacillus bacteriophage φ29 a paradigm for several molecular mechanisms of general biological processes, such as DNAExpand
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The endogenous Bacillus subtilis (natto) plasmids pTA1015 and pTA1040 contain signal peptidase‐encoding genes: identification of a new structural module on cryptic plasmids
Various strains of Bacillus subtilis (natto) contain small cryptic plasmids that replicate via the rolling‐circle mechanism. Like plasmids from other Gram‐positive bacteria, these plasmids areExpand
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Enhancement of DNA, cDNA synthesis and fidelity at high temperatures by a dimeric single-stranded DNA-binding protein.
Bacterial single-stranded DNA-binding proteins (SSBs) are required for DNA replication and repair. We have over-expressed and purified the native form and two His-tagged fusions of the SSB fromExpand
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Inhibition of Bacillus subtilis natural competence by a native, conjugative plasmid-encoded comK repressor protein.
Under certain growth conditions, Bacillus subtilis can develop natural competence, the state in which it is able to bind, adsorb and incorporate exogenous DNA. Development of competence is a bistableExpand
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Discovery of a new family of relaxases in Firmicutes bacteria
Antibiotic resistance is a serious global problem. Antibiotic resistance genes (ARG), which are widespread in environmental bacteria, can be transferred to pathogenic bacteria via horizontal geneExpand
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Characterization of the bacteriophage φ29‐encoded protein p16.7: a membrane protein involved in phage DNA replication
An early expressed operon, located at the right end of the linear bacteriophage φ29 genome, contains open reading frame (ORF)16.7, whose deduced protein sequence of 130 amino acids is conserved inExpand
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Molecular basis for the exploitation of spore formation as survival mechanism by virulent phage ϕ29
Phage ϕ29 is a virulent phage of Bacillus subtilis with no known lysogenic cycle. Indeed, lysis occurs rapidly following infection of vegetative cells. Here, we show that ϕ29 possesses a powerfulExpand
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