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Solid lipid nanoparticles: production, characterization and applications.
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals.
Lipid nanoparticles for improved topical application of drugs for skin diseases.
Solid lipid nanoparticles (SLN) for controlled drug delivery. I. Production, characterization and sterilization
Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron…
Cytotoxicity of Solid Lipid Nanoparticles as a Function of the Lipid Matrix and the Surfactant
- R. Müller, D. Rühl, S. Runge, K. Schulze-Forster, W. Mehnert
- Biology, MedicinePharmaceutical Research
- 1 April 1997
The SLNs appear suitable as a drug carrier system for potential intravenous use due to their very low cytotoxicity in vitro, compared to polyalkylcyanoacrylate and polylactic/glycolic acid (PLA/ GA) nanoparticles.
Solid lipid nanoparticles (SLN) for controlled drug delivery. II. Drug incorporation and physicochemical characterization.
The optimized production parameters previously established for drug-free SLN dispersions can therefore be transferred to drug-loaded systems to facilitate product development.
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
Solid lipid nanoparticles of optimized composition proved to be physically stable during sterilization (autoclaving) and on long-term as aqueous dispersion as well as in vitro drug release over 5 weeks (prednisolone).