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Transplant Glomerulopathy: Morphology, Associations and Mechanism
Transplant glomerulopathy (TG) is a lesion with specific morphology and strong evidence of an immune mechanism. The incidence of TG is approximately 20% by 5 years after transplantation. TG is… Expand
De novo membranous nephropathy associated with donor‐specific alloantibody
Abstract: Recent evidence suggests that alloantibody may play an aetiological role in the pathogenesis of membranous glomerulopathy in native kidneys. There is an increased awareness of the… Expand
Defining the Role of Renal Transplantation in the Modern Management of Multiple Myeloma and Other Plasma Cell Dyscrasias
Plasma cell dyscrasias (PCD) are due to an abnormal proliferation of a single clone of plasma or lymphoplasmacytic cells leading to secretion of immunoglobulin (Ig) or an Ig fragment, causing the… Expand
A critical and exegetical commentary on Jeremiah
- W. Mckane
Praise for Jeremiah: ..".this is the commentary to purchase, cherish and meditate upon day and night... I feel that McKane is due a standing ovation from all the other players currently operating in… Expand
Polymorphism in the human anti-pig natural antibody repertoire: implications for antigen-specific immunoadsorption.
BACKGROUND Anti-Galalpha1-3Gal antibodies cause hyperacute rejection (HAR) in pig-to-primate xenotransplantation. Long-term graft survival has not been achieved despite abrogation of HAR using… Expand
Chloramine-induced haemolysis presenting as erythropoietin resistance.
- S. Fluck, W. Mckane, +7 authors D. Taube
- Nephrology, dialysis, transplantation : official…
- 1 July 1999
BACKGROUND In December 1996 we identified an outbreak of erythropoietin (rHuEpo) resistance requiring a substantial increase in rHuEpo dosage in one of our four haemodialysis (HD) units. The… Expand
Natural History of Proteinuria in Renal Transplant Recipients Developing De Novo Human Leukocyte Antigen Antibodies
Background. The relationship between humoral rejection and human leukocyte antigen (HLA) antibodies is established. Proteinuria is the hallmark of glomerular injury. The relationship between HLA… Expand
Demonstration of IgM antibodies of high affinity within the anti-Galalpha1-3Gal antibody repertoire.
- J. Lee, T. Cairns, W. Mckane, M. Rashid, A. George, D. Taube
- Chemistry, Medicine
- 27 October 1998
BACKGROUND Human anti-Galalpha1-3Gal IgG and IgM xenoantibodies can distinguish between very similar epitopes with a high degree of selectivity. METHODS Anti-Galalpha1-3Gal antibodies were affinity… Expand
Vacuum-assisted closure (VAC) therapy in the management of wound infection following renal transplantation.
OBJECTIVES Wound infection in the setting of immunosuppressed state such as renal transplantation (RT) causes significant morbidity from sepsis, prolongs hospital stay and is expensive.… Expand
Catheter access for hemodialysis defines higher mortality in late-presenting dialysis patients
Background: This study explores the relationship between mortality and late presentation for dialysis, focusing on the role of catheter access for hemodialysis (HD). Methods: We analyzed data from a… Expand