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NO‐naproxen vs. naproxen: ulcerogenic, analgesic and anti‐inflammatory effects
Background: A novel class of nitric oxide‐releasing nonsteroidal anti‐inflammatory drug (NO‐NSAID) derivatives has recently been described which exert anti‐inflammatory activities but produceExpand
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Enhanced anti-inflammatory effects of a nitric oxide-releasing derivative of mesalamine in rats.
BACKGROUND & AIMS Nitric oxide (NO)-releasing derivatives of cyclooxygenase inhibitors exhibit enhanced anti-inflammatory activity and greatly reduced gastrointestinal toxicity. We evaluated whetherExpand
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Technical validation of the Di3D stereophotogrammetry surface imaging system.
The purpose of this work was to assess the technical performance of a three-dimensional surface imaging system for geometric accuracy and maximum field of view. The system was designed forExpand
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Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative.
Effects of a nitroxybutylester derivative of aspirin (NCX 4215) on platelet aggregation and prostanoid synthesis were compared to the effects of aspirin. NCX 4215 was approximately seven times moreExpand
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Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Aspirin decreases the risk of colorectal cancer, reportedly through suppression of cyclooxygenase (COX) activity. Using a rat model of colonic adenocarcinoma, we compared the chemopreventativeExpand
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In vivo antithrombotic effects of a nitric oxide-releasing aspirin derivative, NCX-4016.
entirely attributable to the nitric oxide released from the compound, as it was found to be completely devoid of any inhibitory activity on throm
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Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach.
The role of endothelin, an endothelium-derived constricting factor, as a mediator of gastric ulceration was assessed using an ex vivo gastric chamber model in the rat. The rats were pretreated withExpand
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Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
NSAIDs can elevate blood pressure through mechanisms such as renal vasoconstriction and sodium retention. These effects are particularly evident in hypertensive individuals. Nitric oxide-releasingExpand
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Virtual surgical planning and CAD/CAM in the treatment of cranial defects.
The purpose of this work was to enhance the clinical outcome in the neurosurgical treatment of cranial defects and fibrous dysplasia. Cranial defects require repair using a variety of materials toExpand
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3D surface accuracy of CAD generated skull defect contour.
The creation of a satisfactory cosmetic outcome in the repair of cranial defects relies on manual skill. Expand
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