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RDH10 Oxidation of Vitamin A Is a Critical Control Step in Synthesis of Retinoic Acid during Mouse Embryogenesis
A new targeted knockout of Rdh10 is described in which RA synthesis is severely impaired, particularly at critical early embryonic stages, and RDH10-mediated oxidation of retinol plays as important a role in the control and regulation of RA production during embryogenesis as does the subsequent RALDH-mediated reaction.
Ribosomal DNA copy number loss and sequence variation in cancer
Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs
Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's β-secretase
Evidence that heparan sulfate (HS) interacts with β-site APP-cleaving enzyme (BACE) 1 and regulates its cleavage of APP is reported and a novel mechanism for control of APP processing is suggested.
Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.
The hit identification, the selected strategy for potency optimization, the structure-activity relationships of a hundred analogues synthesized, and the results of the in vivo efficacy studies performed with the lead compound 65 are reported.
Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation
It is shown that Eggless (Egg), a H3K9 methyltransferase in Drosophila, is required in GSCs for controlling self-renewal and in escort cells for regulating germ cell differentiation, revealing the essential roles of histone H3k9 trimethylation in controlling stem cell maintenance and differentiation through distinct mechanisms.
Cohesin Proteins Promote Ribosomal RNA Production and Protein Translation in Yeast and Human Cells
It is demonstrated that the cohesinopathy mutations eco1-W216G and smc1-Q843Δ are associated with defects in ribosome biogenesis and a reduction in the actively translating fraction of ribosomes, eiF2α-phosphorylation, and 35S-methionine incorporation, all of which indicate a deficit in protein translation.
Piwi Is Required in Multiple Cell Types to Control Germline Stem Cell Lineage Development in the Drosophila Ovary
New germline requirement of Piwi in controlling GSC maintenance and lineage differentiation as well as its new somatic function in promoting germ cell differentiation are revealed.
Lung surfactant protein A provides a route of entry for respiratory syncytial virus into host cells.
SP-A enhances the attachment of RSV and subsequent entry into host cells and the effect of SP-A on viral uptake by epithelial cells and macrophage may determine both innate and adaptive immune responses to RSV.
Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands.
Results indicate that FucT-VII is capable of generating complex selectin ligands, in vitro, however the order of fucose addition to the lactosamine chain affects the rate of selectinligand synthesis.