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The mTOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice.
TLDR
The hyperproliferative phenotype of endometriotic cells was associated with an increase in endogenous oxidative stress, and with activation of the ERK and mTOR/AKT pathways. Expand
Association of MicroRNA‐618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis
TLDR
This study investigated potential microRNA (miRNA)–mediated epigenetic mechanisms underlying PDC dysregulation and type I IFN production in SSc, a disease in which PDCs infiltrate fibrotic skin lesions and produce higher levels of IFNα than those in healthy controls. Expand
Arsenic Trioxide Prevents Murine Sclerodermatous Graft-versus-Host Disease
TLDR
A dramatic improvement provided in the model of sclerodermatous GVHD that associates fibrosis with immune activation provides a rationale for the evaluation of As2O3 in the management of patients affected by chronic GV HD. Expand
Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment
TLDR
This review will summarize studies describing the commonly used and validated biomarkers, the newly emerging and promising SSc biomarkers identified to date, and consideration of future directions in this field. Expand
Amelioration of systemic fibrosis in mice by angiotensin II receptor blockade.
TLDR
Irbesartan, an AT1 antagonist, prevents fibrosis and inflammation and inhibits nitric oxide production in HOCl-induced models of systemic fibrosis, extending the indication of an AT 1 antagonist to SSc patients with diffuse fibrosis , especially those with lung involvement. Expand
Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia–reperfusion injury
TLDR
Clopidogrel exerts protective effects on renal ischaemia‐reperfusion injury in mice by abrogating renal cell apoptosis as a consequence of improved renal antioxidant capacity and could be tried as a novel therapeutic tool in renal IRI. Expand
The natural organosulfur compound dipropyltetrasulfide prevents HOCl-induced systemic sclerosis in the mouse
TLDR
The natural organosulfur compound DPTTS prevents skin and lung fibrosis in the mouse through the selective killing of diseased fibroblasts and its immunomodulating properties. Expand
Reactive oxygen species-mediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a murine model of systemic sclerosis.
TLDR
The findings indicate that treatment with As(2) O(3) dramatically improves skin and lung fibrosis in a mouse model of SSc, providing a rationale for the evaluation of As( 2) O (3) treatment in patients with SSc. Expand
Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis.
TLDR
It is shown that miR-483-5p is up-regulated in the serum of SSc patients, from the early stages of the disease onwards, and indicated its potential function as a fine regulator of fibrosis in SSc. Expand
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