• Publications
  • Influence
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
TLDR
It has been shown that buprenorphine is a partial agonist of the mu type which both suppressed and precipitated abstinence in the morphine-dependent dog while morphine and propoxyphene are stronger agonists. Expand
Opioid antagonists.
Methods for evaluating addiction liability. (A) "Attitude" of opiate addicts toward opiate-like drugs. (B) a short-term "direct" addiction test.
TLDR
A short, "double-blind," direct addiction, cross-over procedure of 18 to 20 days is satisfactory for developing significant degrees of physical dependence in the case of morphine and codeine-like drugs, but additional studies are necessary to determine its reliability for assessing the degree ofPhysical dependence induced by weak compounds and compounds in the methadone and meperidine series. Expand
Pharmacology of opioids.
  • W. Martin
  • Biology, Medicine
  • Pharmacological reviews
  • 1 December 1983
TLDR
There is considerable variability between species in both the specificity and selectivity of opioid receptors, and better characterization of the pharmacological profiles and receptor binding specificity for different species may help resolve some of the apparent disparities. Expand
The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.
TLDR
Data from the study of morphine-like and nalorphine-like drugs studied in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog are consistent with the hypothesis that there are strong and partial agonists of the mu and kappa types, and further, that physical dependence on morphine and cyclzocine is mediated through different receptors. Expand
Naltrexone, an antagonist for the treatment of heroin dependence. Effects in man.
TLDR
Naltrexone appears to be a relatively pure potent narcotic antagonist which is effective orally and which may have utility in the treatment of heroin and narcotic dependence. Expand
A COMPARISON BETWEEN ACUTE AND CHRONIC PHYSICAL DEPENDENCE IN THE CHRONIC SPINAL DOG.
TLDR
It is suggested that acute and chronic tolerance as well as acute and Chronic physical dependence are, to an extent, qualitatively different and suggest there may be several mechanisms involved in the development of tolerance to and physical dependence on morphine. Expand
AGONISTS AND ANTAGONISTS
1 A brief history of the development of narcotic antagonists is outlined. 2 Theclinicalandpharmacologicalobservationsleadingtothediscoveryofdualismofopiatereceptors are reviewed. 3 An extension ofExpand
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