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The hydrogen hypothesis for the first eukaryote
A new hypothesis for the origin of eukaryotic cells is proposed, based on the comparative biochemistry of energy metabolism, to have arisen through symbiotic association of an anaerobic, strictly hydrogen-dependent, strictly autotrophic archaebacterium with a eubacterium.
Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements
Genetic analysis of the wMel genome further supports the hypothesis that mitochondria share a common ancestor with the α-Proteobacteria, but shows little support for the grouping of mitochondria with species in the order Rickettsiales.
Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus
- W. Martin, T. Rujan, D. Penny
- Biology, Environmental ScienceProceedings of the National Academy of Sciences…
- 6 September 2002
A phylogeny of chloroplast genomes inferred from 41 proteins and 8,303 amino acids sites indicates that at least two independent secondary endosymbiotic events have occurred involving red algae and that amino acid composition bias in chloropleft proteins strongly affects plastid genome phylogeny.
Endosymbiotic gene transfer: organelle genomes forge eukaryotic chromosomes
Genome sequences reveal that a deluge of DNA from organelle DNA has constantly been bombarding the nucleus since the origin of organelles, abolished organelle autonomy and increased nuclear complexity.
Hydrothermal vents and the origin of life
Submarine hydrothermal vents are geochemically reactive habitats that harbour rich microbial communities. There are striking parallels between the chemistry of the H2–CO2 redox couple that is present…
Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes
The frequency of numt insertions among 85 sequenced eukaryotic genomes reveal that numt content is strongly correlated with genome size, suggesting that the numt insertion rate might be limited by DSB frequency.
Eukaryotic evolution, changes and challenges
The idea that some eukaryotes primitively lacked mitochondria and were true intermediates in the prokaryote-to-eukaryote transition was an exciting prospect, but the evolutionary gap between proKaryotes and eUKaryotes is now deeper, and the nature of the host that acquired the mitochondrion more obscure, than ever before.
Biochemistry and Evolution of Anaerobic Energy Metabolism in Eukaryotes
The gene distribution across lineages reflects the presence of anaerobic energy metabolism in the eukaryote common ancestor and differential loss during the specialization of some lineages to oxic niches, just as oxphos capabilities have been differentially lost in specialization to anoxic niches and the parasitic life-style.
Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.
- B. M. Lange, T. Rujan, W. Martin, R. Croteau
- BiologyProceedings of the National Academy of Sciences…
- 21 November 2000
The results suggest that lateral gene transfer between eubacteria subsequent to the origin of plastids has played a major role in the evolution of this pathway.
On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells.
The universal ancestor the authors infer was not a free-living cell, but rather was confined to the naturally chemiosmotic, FeS compartments within which the synthesis of its constituents occurred, leading to the emergence of prokaryotic lineages from inorganic confines.