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The Chlamydomonas Genome Reveals the Evolution of Key Animal and Plant Functions
TLDR
Analyses of the Chlamydomonas genome advance the understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
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Interphase chromosomes undergo constrained diffusional motion in living cells
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Ciliogenesis: building the cell's antenna
TLDR
As cilia are important in sensing and processing developmental signals and directing the flow of fluids such as mucus, defects in ciliogenesis and length control are likely to underlie a range of cilium-related human diseases.
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Intraflagellar transport balances continuous turnover of outer doublet microtubules
TLDR
A simple steady-state model for flagellar length regulation is determined by which a balance of assembly and disassembly can effectively regulate flageLLar length.
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Mitosis in living budding yeast: anaphase A but no metaphase plate.
TLDR
Budding yeast did not exhibit a conventional metaphase chromosome alignment but did show anaphase A, movement of the chromosomes to the poles, and centromeres separated before telomeres.
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Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA.
TLDR
Analysis of the three-dimensional structure and dynamics of mitochondria in living cells with wide-field fluorescence microscopy indicated that mitochondria form a single dynamic network, whose continuity is maintained by a balanced frequency of fission and fusion events, which can be explained by the formation of one continuous mitochondrial compartment after mating.
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Homologous Chromosome Pairing in Drosophila melanogaster Proceeds through Multiple Independent Initiations
TLDR
It is concluded that simple random contacts through diffusion could suffice to allow pairing of homologous sites, and the observed pairing kinetics are most consistent with a constrained random walk model and not inconsistent with a directed motion model.
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Flagellar length control system: testing a simple model based on intraflagellar transport and turnover.
TLDR
The model proposes a mechanism for flagellar length control in which length is set by the balance of continuous flageLLar assembly and disassembly, which finds that the quantity of intraflagllar transport machinery is independent of length, that flagelliar length is a decreasing function of flageellar number, and that flagesllar growth rate in regenerating flagella depends on length and not on the time since regeneration began.
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Intraflagellar transport particle size scales inversely with flagellar length: revisiting the balance-point length control model
Chlamydomonas reinhardtii IFT particle trains, important for flagella maintenance and assembly, are observed to decrease in size as a function of cilia length.
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Proteomic Analysis of Isolated Chlamydomonas Centrioles Reveals Orthologs of Ciliary-Disease Genes
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