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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring… Expand
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, +166 authors G. Kroemer
- Medicine, Biology
- Cell Death & Differentiation
- 23 January 2018
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional… Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the… Expand
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
- G. Kroemer, L. Galluzzi, +19 authors G. Melino
- Medicine, Biology
- Cell Death and Differentiation
- 25 October 2005
Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposes… Expand
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
Cell death is essential for a plethora of physiological processes, and its deregulation characterizes numerous human diseases. Thus, the in-depth investigation of cell death and its mechanisms… Expand
Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities.
The migration capability of dendritic cells (DCs) is regulated by their response to factors, namely chemokines, that characterize maturation stage and shape their functional activities. This study… Expand
IL-12 induces IFN-gamma expression and secretion in mouse peritoneal macrophages.
We previously reported that resting mouse peritoneal macrophages (PM) constitutively express low levels of IFN-gamma, whose production is consistently enhanced by exogenous IFN-gamma. In this study,… Expand
Cannibalism of live lymphocytes by human metastatic but not primary melanoma cells.
The phenomenon of cell cannibalism, which generally refers to the engulfment of cells within other cells, was described in malignant tumors, but its biological significance is still largely unknown.… Expand
CD95 (APO‐1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway
CD95 (APO‐1/Fas) is a member of the tumor necrosis factor receptor family, which can trigger apoptosis in a variety of cell types. However, little is known of the mechanisms underlying cell… Expand
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli
- V. Costa, M. Giacomello, +7 authors L. Scorrano
- Biology, Medicine
- EMBO molecular medicine
- 1 December 2010
Huntington's disease (HD), a genetic neurodegenerative disease caused by a polyglutamine expansion in the Huntingtin (Htt) protein, is accompanied by multiple mitochondrial alterations. Here, we show… Expand