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Derivatives of pyrrolo[3,4-d]pyridazinone, a new class of analgesic agents.
A series of N2-{2-[4-aryl(benzyl)-1-piperazinyl(piperidinyl)]ethyl}pyrrolo[3,4-d]pyridazinones 4 and related derivatives 5 were synthesized as potential analgesic agents. The structures of the newExpand
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Synthesis and analgesic action of N-(substituted-ethyl)pyrrole-3,4-dicarboximides.
We prepared a series of new N-[2-(4-substitutedpiperazin-1-yl)ethyl]-1-(n-butyl or phenyl)-2,5-dimethyl-3,4-pyrroledicarboximides 3 and the related products 4 and 5, nine representatives of whichExpand
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Synthesis and anorectic activity of 2H-4,6-dimethyl-2-[(4- phenylpiperazin-1-yl)methyl]-3-oxo-2,3-dihydroisothiazolo[5,4-b]pyridin e.
The synthesis of 2H-4,6-dimethyl-2-[(4- phenylpiperazin-1-yl)methyl]-3-oxo-2,3-dihydroisothiazolo[5, 4-b]pyridine. (3) and its biological properties are described. Compound 3 pharmacologicallyExpand
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Synthesis and preliminary screening of derivatives of 2-(4-arylpiperazin-1-ylalkyl)-3-oxoisothiazolo[5,4-b] pyridines as CNS and antimycobacterial agents.
We have synthesized several new isothiazolopyridines possessing a side chain at the isothiazole ring typical, among others, for trazodone or NAN-195. Representatives of the novel isothiazolopyridinesExpand
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New derivatives of pyrrolo[3,4-d]pyridazinone and their anticancer effects.
Eighteen new derivatives of pyrrolo[3,4-d]pyridazinone modified at the pyrrole and pyridazine rings were synthesized and 12 of them were evaluated in vitro through anticancer screenings. TheExpand
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Synthesis of some pyrrolo[3,4-d]pyridazinones and their preliminary anticancer, antimycobacterial and CNS screening.
  • W. Malinka
  • Chemistry, Medicine
  • Die Pharmazie
  • 1 May 2001
Starting from 1-substituted-2,5-dimethyl-3,4-pyrroledicarboxylic acid anhydrides 1 and N-methylhydrazine, 1,2,3,4-tetrahydro-6-substituted-2,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin- 1,4-ones 2 wereExpand
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Synthesis of some N-substituted 3,4-pyrroledicarboximides as potential CNS depressive agents.
As a continuation of our work on N-[4-aryl(heteroaryl)piperazin-1-ylalkyl]-3,4-pyrro ledicarboximides, which were characterized by strong analgesic activity and CNS depressive action, several novelExpand
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Synthesis and pharmacological screening of some N-(4-substituted-piperazin-1-ylalkyl)-3,4-pyrroledicarboximides.
As an extension of our previous work we describe the synthesis and pharmacological investigation of a new series of derivatives of pyrrole-3,4-dicarboximide possessing theExpand
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Synthesis and biological evaluation of derivatives of N-[4-substituted-1-piperazinylalkyl]-1-(butyl,aryl)-2,5- dimethylpyrrole-3,4-dicarboxymide (Part II).
A series of new N-[4-substituted-1-piperazinyl-alkyl]-3,4-pyrroledicarboxyimides 7 have been prepared by reaction of N-haloalkylimide derivatives 6 with corresponding N-monosubstituted piperazines.Expand
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