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Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.
BACKGROUND Hyperlipidemia has been suggested as a risk factor for stenosis of the aortic valve, but lipid-lowering studies have had conflicting results. METHODS We conducted a randomized,Expand
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Outcome of Patients With Low-Gradient “Severe” Aortic Stenosis and Preserved Ejection Fraction
Background— Retrospective studies have suggested that patients with a low transvalvular gradient in the presence of an aortic valve area <1.0 cm2 and normal ejection fraction may represent a subgroupExpand
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Pharmacokinetics, Bioavailability, and Safety of Montelukast Sodium (MK-0476) in Healthy Males and Females
AbstractPurpose. The safety, tolerability, and pharmacokinetics of intravenous (i.v.) montelukast sodium (Singulair™, MK-0476), and the oral bioavailability of montelukast sodium in healthy males andExpand
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Oral Rizatriptan Versus Oral Sumatriptan: A Direct Comparative Study in the Acute Treatment of Migraine
Rizatriptan is a potent, oral, 5‐HT1B/1D agonist with more rapid absorption and higher bioavailability than oral sumatriptan. It was postulated that this would result in more rapid onset of effect.Expand
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Desynchronization of the oral temperature circadian rhythm and intolerance to shift work
The present study tested the hypothesis that subjects with a good tolerance to shift work maintain the circadian period τ of their temperature rhythm equal to 24 h, while τ may differ from 24 h whenExpand
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Design and baseline characteristics of the simvastatin and ezetimibe in aortic stenosis (SEAS) study.
Aortic valve stenosis and atherosclerotic disease have several risk factors in common, in particular, hypercholesterolemia. Histologically, the diseased valves appear to have areas of inflammationExpand
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Eff ects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure ( HEAAL study ) : a randomised , double-blind trial
Methods This double-blind trial was undertaken in 255 sites in 30 countries. 3846 patients with heart failure of New York Heart Association class II–IV, left-ventricular ejection fraction 40% orExpand
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Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine
Objective: To investigate the clinical profile of rofecoxib, a long-acting (≈17-hour half-life) selective cyclo-oxygenase-2 inhibitor, for the acute treatment of migraine. Methods: A randomized,Expand
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A risk score for predicting mortality in patients with asymptomatic mild to moderate aortic stenosis
Background Prognostic information for asymptomatic patients with aortic stenosis (AS) from prospective studies is scarce and there is no risk score available to assess mortality. Objectives ToExpand
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