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Human Catechol-O-Methyltransferase Haplotypes Modulate Protein Expression by Altering mRNA Secondary Structure
Catechol-O-methyltransferase (COMT) is a key regulator of pain perception, cognitive function, and affective mood. Three common haplotypes of the human COMT gene, divergent in two synonymous and oneExpand
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Genetic basis for individual variations in pain perception and the development of a chronic pain condition.
Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity. We identifiedExpand
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GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, is a key modulator of peripheral neuropathic and inflammatory pain. BH4 is an essentialExpand
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Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
&NA; Variations in the gene encoding catechol‐O‐methyltransferase (COMT) are linked to individual differences in pain sensitivity. A single nucleotide polymorphism (SNP) in codon 158 (val158met),Expand
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Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain
&NA; Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. We determined whether patients withExpand
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Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode.
Temporal summation of sensory intensity was investigated in normal subjects using novel methods of thermal stimulation. A Peltier thermode was heated and then applied in a series of brief (700 ms)Expand
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Interactions between cardiovascular and pain regulatory systems
A review of pharmacological, neuroanatomical, electrophysiological, and behavioral data indicates that systems controlling cardiovascular function are closely coupled to systems modulating theExpand
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Idiopathic pain disorders – Pathways of vulnerability
Idiopathic pain disorders (IPDs) consist of such conditions as temporomandibular joint disorders (TMJD), fibromyalgia syndrome (FMS), irritable bowel syndrome (IBS), chronic headaches, interstitialExpand
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Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain: evidence for altered temporal summation of pain
&NA; Temporomandibular disorders (TMD) represent a group of chronic painful conditions involving the muscles of mastication and the temporomandibular joint. Several studies have reported that TMD isExpand
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Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1.
Not all patients with nerve injury develop neuropathic pain. The extent of nerve damage and age at the time of injury are two of the few risk factors identified to date. In addition, preclinicalExpand
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