W. M. Hempel

Publications13
h-index10
Citations685
Highly Influential Citations31
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Affinity Purification of Mammalian RNA Polymerase I
Overlapping cDNA clones encoding the two largest subunits of rat RNA polymerase I, designated A194 and A127, were isolated from a Reuber hepatoma cDNA library. Analyses of the deduced amino acid… Expand
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Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination.
Gene targeting studies have shown that T cell receptor (TCR)-beta gene expression and recombination are inhibited after deletion of an enhancer (Ebeta) located at the 3' end of the approximately… Expand
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Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development
Gene targeting studies have shown that T cell receptor (TCR)-β gene expression and recombination are inhibited after deletion of an enhancer (Eβ) located at the 3′ end of the ∼500-kb TCR-β locus.… Expand
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TCRα enhancer activation occurs via a conformational change of a pre‐assembled nucleo‐protein complex
The TCR α enhancer (Eα) has served as a paradigm for studying how enhancers organize trans‐activators into nucleo‐protein complexes thought to recruit and synergistically stimulate the… Expand
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Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system.
Traditional models for transcription initiation by RNA polymerase I include a stepwise assembly of basic transcription factors/regulatory proteins on the core promoter to form a preinitiation… Expand
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Accessibility control of V(D)J recombination: lessons from gene targeting.
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Assessing the Role of the T Cell Receptor β Gene Enhancer in Regulating Coding Joint Formation during V(D)J Recombination*
To assess the role of the T cell receptor (TCR) β gene enhancer (Eβ) in regulating the processing of VDJ recombinase-generated coding ends, we assayed TCRβ rearrangement of Eβ-deleted (ΔEβ)… Expand
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Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.
Deletion of the TCRbeta transcriptional enhancer (Ebeta) results in nearly complete inhibition of V(D)J recombination at the TCRbeta locus and a block in alpha beta T cell development. This result,… Expand
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Definition of a T-Cell Receptor β Gene Core Enhancer of V(D)J Recombination by Transgenic Mapping
ABSTRACT V(D)J recombination in differentiating lymphocytes is a highly regulated process in terms of both cell lineage and the stage of cell development. Transgenic and knockout mouse studies have… Expand
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The species-specific RNA polymerase I transcription factor SL-1 binds to upstream binding factor.
Transcription of the 45S rRNA genes is carried out by RNA polymerase I and at least two trans-acting factors, upstream binding factor (UBF) and SL-1. We have examined the hypothesis that SL-1 and UBF… Expand
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