• Publications
  • Influence
Retinoic acid X receptor in the diploblast, Tripedalia cystophora.
TLDR
It is shown by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs), suggesting that RXR is an early component of the regulatory mechanisms of metazoa. Expand
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity.
TLDR
XF-73 exhibited rapid membrane-perturbing activity, which is likely to be responsible for inhibition of macromolecular synthesis and the death of staphylococci exposed to the drug. Expand
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms.
TLDR
The results support the hypothesis that membrane-active agents may be particularly effective in eradicating slow- or non-growing bacteria and suggest that XF-70 andXF-73 could be utilized to treat staphylococcal infections where the organisms are only dividing slowly, such as biofilm-associated infections of prosthetic devices. Expand
Investigation of the Potential for Mutational Resistance to XF-73, Retapamulin, Mupirocin, Fusidic Acid, Daptomycin, and Vancomycin in Methicillin-Resistant Staphylococcus aureus Isolates during a
TLDR
XF-73 represents the first in a new class of antibacterial drugs, which after 55 passages exhibited a ≤4-fold increase in MIC against the strains tested, which is much needed for the prevention and treatment of multidrug-resistant bacteria both within and outside the hospital setting. Expand
In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species.
TLDR
XF-73 represents a novel broad-spectrum Gram-positive antibacterial drug with potentially beneficial characteristics for the treatment and prevention of Gram- positive bacterial infections. Expand
Liposome‐Mediated Delivery of Photosensitizers: Localization of Zinc (11)‐Phthalocyanine within Implanted Tumors after Intravenous Administration
TLDR
The photosensitizer was found in association with blood vessels at 3 h but not 24 h after dosing and appeared to have a greater affinity for areas of tissue necrosis within the tumor compared to viable tumor tissue. Expand
Properties of disulfide-linked tubulin purified on hydroxyapatite and its comparison with intact and dissociated microtubules using limited tryptic digestion.
TLDR
Limited proteolysis was found to offer a useful probe of tubulin structure and to produce fragments which might prove valuable in analyzing its protein substructure. Expand
In vitro interaction of zinc(II)-phthalocyanine-containing liposomes and plasma lipoproteins.
TLDR
The buoyant density of Zn-Pc liposomes increased in a dose-dependent fashion when the particles were incubated with plasma, and it is suggested that this was due, at least in part, to opsonization of liposome by plasma proteins. Expand
Calcium-binding phospholipids as a coating material for implant osteointegration
TLDR
It is demonstrated that calcium-binding phospholipids can be used as biomimetic coating materials for improving the osteointegration of metal implants and that the homogeneous phosphatidylserine coating was a more effective calcification environment than the heterogeneous formulations. Expand
In vivo assessment of the osteointegrative potential of phosphatidylserine-based coatings
TLDR
Assessment of the osteointegrative potential of a novel biomimetic approach where porous titanium implants are coated with calcium-binding phospholipids in an in vivo rabbit model shows that phosphatidylserine-based coatings, whilst resorbing, drive the growing bone into apposition with the metal surface. Expand
...
1
2
3
...