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Retinoic acid X receptor in the diploblast, Tripedalia cystophora.
- Z. Kostrouch, M. Kostrouchová, W. Love, E. Jannini, J. Piatigorsky, J. E. Rall
- BiologyProceedings of the National Academy of Sciences…
- 10 November 1998
It is shown by cDNA and gene cloning that a Cnidarian, Tripedalia cystophora, possesses a retinoid receptor (jRXR) with remarkable homology to vertebrate retinoic acid X receptors (RXRs), suggesting that RXR is an early component of the regulatory mechanisms of metazoa.
Investigation of the Potential for Mutational Resistance to XF-73, Retapamulin, Mupirocin, Fusidic Acid, Daptomycin, and Vancomycin in Methicillin-Resistant Staphylococcus aureus Isolates during a…
- D. Farrell, M. Robbins, W. Rhys-Williams, W. Love
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 13 December 2010
XF-73 represents the first in a new class of antibacterial drugs, which after 55 passages exhibited a ≤4-fold increase in MIC against the strains tested, which is much needed for the prevention and treatment of multidrug-resistant bacteria both within and outside the hospital setting.
XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity.
- N. Ooi, K. Miller, Joanne K. Hobbs, W. Rhys-Williams, W. Love, I. Chopra
- BiologyJournal of Antimicrobial Chemotherapy
- 1 October 2009
XF-73 exhibited rapid membrane-perturbing activity, which is likely to be responsible for inhibition of macromolecular synthesis and the death of staphylococci exposed to the drug.
XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms.
- N. Ooi, K. Miller, C. Randall, W. Rhys-Williams, W. Love, I. Chopra
- BiologyThe Journal of antimicrobial chemotherapy
The results support the hypothesis that membrane-active agents may be particularly effective in eradicating slow- or non-growing bacteria and suggest that XF-70 andXF-73 could be utilized to treat staphylococcal infections where the organisms are only dividing slowly, such as biofilm-associated infections of prosthetic devices.
Liposome‐Mediated Delivery of Photosensitizers: Localization of Zinc (11)‐Phthalocyanine within Implanted Tumors after Intravenous Administration
- W. Love, S. Duk, R. Biolo, G. Jori, P. Taylor
- Medicine, BiologyPhotochemistry and photobiology
- 1 May 1996
The photosensitizer was found in association with blood vessels at 3 h but not 24 h after dosing and appeared to have a greater affinity for areas of tissue necrosis within the tumor compared to viable tumor tissue.
In vitro activity of XF-73, a novel antibacterial agent, against antibiotic-sensitive and -resistant Gram-positive and Gram-negative bacterial species.
Extracellular and intracellular bactericidal activities of XF-70 against small-colony variant hemB mutants of meticillin-susceptible and meticillin-resistant Staphylococcus aureus.
In vitro interaction of zinc(II)-phthalocyanine-containing liposomes and plasma lipoproteins.
Properties of disulfide-linked tubulin purified on hydroxyapatite and its comparison with intact and dissociated microtubules using limited tryptic digestion.
Calcium-binding phospholipids as a coating material for implant osteointegration
- M. Santin, W. Rhys-Williams, S. Denyer
- Materials Science, BiologyJournal of the Royal Society Interface
- 22 April 2006
It is demonstrated that calcium-binding phospholipids can be used as biomimetic coating materials for improving the osteointegration of metal implants and that the homogeneous phosphatidylserine coating was a more effective calcification environment than the heterogeneous formulations.