• Publications
  • Influence
MicroRNA‐17∼92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways
MicroRNAs (miRNAs) have been broadly implicated in cancer, but their exact function and mechanism in carcinogenesis remain poorly understood. Elevated miR‐17∼92 expression is frequently found inExpand
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Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation
The physiological activity of Notch is a function of its ability to increase survival in many cell types. Several pathways have been shown to contribute to the survival effect of Notch, but the exactExpand
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Deltex Regulates T-Cell Activation by Targeted Degradation of Active MEKK1
  • W. Liu, M. Lai
  • Biology, Medicine
  • Molecular and Cellular Biology
  • 15 February 2005
ABSTRACT Deltex is known as a Notch signal mediator, but its physiological action mechanism is poorly understood. Here we identified a new regulatory role of Deltex in T-cell activation. DeltexExpand
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A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells
  • W. Liu, S. Kang, +14 authors C. Xiao
  • Medicine, Biology
  • The Journal of experimental medicine
  • 22 August 2016
Xiao and collaborators show that miR-155 regulates T follicular helper cell development and function by suppressing the E3 ubiquitin ligase Peli1.
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Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
Application of regulatory T cells (Tregs) in transplantation, autoimmunity and allergy has been extensively explored, but how Foxp3 and Treg stability is regulated in vivo is incompletely understood.Expand
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Deltex1 Promotes Protein Kinase Cθ Degradation and Sustains Casitas B-Lineage Lymphoma Expression
The generation of T cell anergy is associated with upregulation of ubiquitin E3 ligases including Casitas B-lineage lymphoma (Cbl-b), Itch, gene related to anergy in lymphocyte, and deltex1 (DTX1).Expand
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Noninvasive photoacoustic and fluorescent tracking of optical dye labeled T cellular activities of diseased sites at new depth.
The migration of immune cells is crucial to the immune response. Visualization of these processes has previously been limited because of the imaging depth. We developed a deep-penetrating, sensitiveExpand
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Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy.
The molecular process underlying T cell anergy is incompletely understood. Deltex1 (DTX1) is a Notch target with unknown physiological function. Here we show that Dtx1 was a transcription target ofExpand
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Differential Sensitivity of Target Genes to Translational Repression by miR-17~92
MicroRNAs (miRNAs) are thought to exert their functions by modulating the expression of hundreds of target genes and each to a small degree, but it remains unclear how small changes in hundreds ofExpand
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A single base substitution in the variable pocket of yeast tRNA(Arg) eliminates species-specific aminoacylation.
Early biochemical data showed that aminoacyl-tRNA synthetases often displayed species-specific recognition of tRNA. We compared the ability of purified Saccharomyces cerevisiae and Escherichia coliExpand
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