• Publications
  • Influence
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Regulatory T (T reg) cells are critical regulators of immune tolerance. Most T reg cells are defined based on expression of CD4, CD25, and the transcription factor, FoxP3. However, these markers haveExpand
  • 2,324
  • 180
The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation
Regulatory T cells (Treg) are critical regulators of immune tolerance. Both IL‐2 and CD28‐CD80/CD86 signaling are critical for CD4+CD25+FOXP3+ Treg survival in mice. Yet, both belatacept (aExpand
  • 201
  • 16
Steroid receptor heterodimerization demonstrated in vitro and in vivo.
The mineralocorticoid and glucocorticoid receptors (MR and GR, respectively) are members of the intracellular receptor superfamily that bind as homodimers to the same hormone response elementsExpand
  • 196
  • 12
Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes
OBJECTIVE—Regulatory T-cells (Tregs) have catalyzed the field of immune regulation. However, translating Treg-based therapies from animal models of autoimmunity to human clinical trials requiresExpand
  • 322
  • 11
Infusion of Mesenchymal Stem Cells and Rapamycin Synergize to Attenuate Alloimmune Responses and Promote Cardiac Allograft Tolerance
  • W. Ge, J. Jiang, +6 authors H. Wang
  • Medicine
  • American journal of transplantation : official…
  • 1 August 2009
The inherent immunosuppressive properties and low immunogenicity of mesenchymal stems cells (MSCs) suggested their therapeutic potential in transplantation. We investigated whether MSCs could prolongExpand
  • 219
  • 11
Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO.
Defects in natural killer (NK) cell function are necessary for tumor immune escape, but the underlying regulatory mechanisms in human cancers remain largely unknown. Here we show that fibroblastsExpand
  • 131
  • 11
An adenosine nucleoside inhibitor of dengue virus
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year.Expand
  • 149
  • 7
Genome sequences of wild and domestic bactrian camels
  • Zhen Guohui Gangliang Yamin Zhihong Heping Lei Surong Y Jirimutu Wang Ding Chen Sun Sun Zhang Wang Hasi Zh, Jirimutu, +70 authors H. Meng
  • Medicine, Biology
  • Nature communications
  • 13 November 2012
Bactrian camels serve as an important means of transportation in the cold desert regions of China and Mongolia. Here we present a 2.01 Gb draft genome sequence from both a wild and a domesticExpand
  • 101
  • 6
Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering.
Electrospun nanofibers mimic the native extracellular matrix of bone and have generated considerable interest in bone tissue regeneration. The aim of this study was to fabricate novelExpand
  • 189
  • 4
Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells.
Phagocytosis of asbestos fibers may be a necessary step for asbestos-induced injury to mesothelial cells, but this has not been established because quantification of fiber uptake is difficult andExpand
  • 102
  • 3