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Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.
DNA methylation and demethylation have been proposed to play an important role in somatic cell reprogramming. Here, we demonstrate that the DNA hydroxylase Tet1 facilitates pluripotent stem cellExpand
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Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that must be reprogrammed after fertilization. However, the molecular details of these events are lacking in early embryos.Expand
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Enhanced telomere rejuvenation in pluripotent cells reprogrammed via nuclear transfer relative to induced pluripotent stem cells.
Although somatic cell nuclear transfer (SCNT) and induction of pluripotency (to form iPSCs) are both recognized reprogramming methods, there has been relatively little comparative analysis of theExpand
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An elaborate regulation of Mammalian target of rapamycin activity is required for somatic cell reprogramming induced by defined transcription factors.
The mammalian target of the rapamycin (mTOR) signaling pathway functions in many cellular processes, including cell growth, proliferation, differentiation, and survival. Recent advances haveExpand
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Protein Expression Landscape of Mouse Embryos during Pre-implantation Development.
Pre-implantation embryo development is an intricate and precisely regulated process orchestrated by maternally inherited proteins and newly synthesized proteins following zygotic genome activation.Expand
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Overcoming the Problem of Loss-in-Capacity of Calcium Oxide in CO2 Capture
Calcium oxide has been identified to be one of the best candidates for CO2 capture in zero-emission power-generation systems. However, it suffers a well-known problem of loss-in-capacity (i.e., itsExpand
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Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA methylation, which is predominantly mediated by DNMT3A, a de novo DNA methyltransferase1,2. Unlike the genome ofExpand
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A novel RAB7 mutation in a Chinese family with Charcot-Marie-Tooth type 2B disease.
Charcot–Marie–Tooth type 2B (CMT2B) disease is a hereditary motor and sensory neuropathy subtype characterized by prominent loss of sensation, distal muscle weakness and wasting skin ulcers.Expand
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The fate of sulfur during rapid pyrolysis of scrap tires.
The fate of sulfur during rapid pyrolysis of scrap tires at temperatures from 673 to 1073K was investigated. Sulfur was predominant in the forms of thiophenic and inorganic sulfides in raw scrapExpand
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Accurate annotation of accessible chromatin in mouse and human primordial germ cells
Extensive and accurate chromatin remodeling is essential during primordial germ cell (PGC) development for the perpetuation of genetic information across generations. Here, we report that distalExpand
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