Exosomes-mediated transfer of long noncoding RNA ZFAS1 promotes gastric cancer progression
- Lei Pan, W. Liang, Xu Zhang
- Biology, MedicineJournal of Cancer Research and Clinical Oncology
- 11 March 2017
ZFas1 could be delivered by exosomes to promote GC progression, which suggests that ZFAS1 may serve as a potential diagnostic and prognostic biomarker for GC.
The Complex Role of Neutrophils in Tumor Angiogenesis and Metastasis
- W. Liang, N. Ferrara
- Biology, MedicineCancer immunology research
- 1 February 2016
This work highlights recent findings on the mechanisms by which tumor cells, in cooperation with tumor-associated stromal cells, induce expansion, recruitment, and polarization of neutrophils.
Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade.
- Haidong Tang, Yang Wang, yang-xin fu
- Biology, MedicineCancer Cell
- 14 March 2016
SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells
- A. Vultur, R. Buettner, R. Jove
- Biology, MedicineMolecular Cancer Therapeutics
- 1 May 2008
The results show that SKI-606 caused a decrease in cell motility and invasion of breast cancer cell lines with an IC50 of ∼250 nmol/L, which was also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells.
Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin.
- N. Tang, Gangjun Du, Nan Wang, Chunchun Liu, H. Hang, W. Liang
- Biology, MedicineJournal of the National Cancer Institute
- 4 July 2007
A novel PEG-PE-based nanocarrier of doxorubicin that increased cytotoxicity in vitro and enhanced antitumor activity in vivo with low systemic toxicity is developed.
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas
- Fan Yang, T. Van Meter, R. Jove
- Biology, MedicineMolecular Cancer Therapeutics
- 1 November 2008
It is shown that sorafenib blocks STAT3 signaling as well as expression of cell cycle and apoptosis regulatory proteins, associated with inhibition of cell proliferation and induction of apoptosis in medulloblastomas.
Naringenin: a potential immunomodulator for inhibiting lung fibrosis and metastasis.
- Gangjun Du, Lingtao Jin, Xiaofeng Han, Zihui Song, Hongyan Zhang, W. Liang
- Biology, MedicineCancer Research
- 1 April 2009
It is shown that mice with pulmonary fibrosis challenged using tumors show an increased incidence of lung metastasis and shorter life spans compared with the mice without lung fibrosis, suggesting that Naringenin could be an ideal therapeutic agent in the treatment of both cancer and fibrosis.
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.
- H. Xin, A. Herrmann, Hua Yu
- Biology, ChemistryCancer Research
- 1 November 2011
STAT3 has important functions in both tumor cells and the tumor microenvironment to facilitate cancer progression. The STAT regulatory kinase Janus-activated kinase (JAK) has been strongly implicated…
Application of autologous tumor cell vaccine and NDV vaccine in treatment of tumors of digestive tract.
The autologous tumor cell vaccine and NDV vaccine can prolong the patients' life and can be used whenever necessary with good prospects.
Long noncoding RNA LINC00978 promotes cancer growth and acts as a diagnostic biomarker in gastric cancer
- Min Fu, Zhenhua Huang, Xu Zhang
- BiologyCell Proliferation
- 1 February 2018
The potential roles and clinical value of LINC00978 in gastric cancer are investigated and the expression pattern and biological roles remain unclear.
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