• Publications
  • Influence
Mathematical model for studying genetic variation in terms of restriction endonucleases.
  • M. Nei, W. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 October 1979
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotideExpand
  • 9,448
  • 604
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Statistical tests of neutrality of mutations.
Mutations in the genealogy of the sequences in a random sample from a population can be classified as external and internal. External mutations are mutations that occurred in the external branchesExpand
  • 3,548
  • 346
  • PDF
The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.
  • P. Sharp, W. Li
  • Biology, Medicine
  • Nucleic acids research
  • 11 February 1987
A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed. The index uses a reference set of highly expressed genes from a species to assess the relativeExpand
  • 2,841
  • 339
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Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees.
  • F. L. Chen, W. Li
  • Biology, Medicine
  • American journal of human genetics
  • 1 February 2001
To study the genomic divergences among hominoids and to estimate the effective population size of the common ancestor of humans and chimpanzees, we selected 53 autosomal intergenic nonrepetitive DNAExpand
  • 692
  • 69
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Date of the monocot-dicot divergence estimated from chloroplast DNA sequence data.
The divergence between monocots and dicots represents a major event in higher plant evolution, yet the date of its occurrence remains unknown because of the scarcity of relevant fossils. We haveExpand
  • 579
  • 42
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.
A new method is proposed for estimating the number of synonymous and nonsynonymous nucleotide substitutions between homologous genes. In this method, a nucleotide site is classified as nondegenerate,Expand
  • 999
  • 41
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites.
  • X. Gu, Y. Fu, W. Li
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 July 1995
This paper presents a maximum likelihood approach to estimating the variation of substitution rate among nucleotide sites. We assume that the rate varies among sites according to an invariant+gammaExpand
  • 562
  • 38
Low nucleotide diversity in man.
The nucleotide diversity (pi) in humans is studied by using published cDNA and genomic sequences that have been carefully checked for sequencing accuracy. This measure of genetic variability isExpand
  • 462
  • 32
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Evidence for higher rates of nucleotide substitution in rodents than in man.
  • C. Wu, W. Li
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1 March 1985
When the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine), it is found that rodents evolve significantly fasterExpand
  • 857
  • 30
The rate of synonymous substitution in enterobacterial genes is inversely related to codon usage bias.
  • P. Sharp, W. Li
  • Biology, Medicine
  • Molecular biology and evolution
  • 1 May 1987
Genes sequences from Escherichia coli, Salmonella typhimurium, and other members of the Enterobacteriaceae show a negative correlation between the degree of synonymous-codon usage bias and the rateExpand
  • 323
  • 30
  • PDF