• Publications
  • Influence
Neurexin 1α structural variants associated with autism
Neurexins are presynaptic membrane cell-adhesion molecules which bind to neuroligins, a family of proteins that are associated with autism. To explore the possibility that structural variants in theExpand
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Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway
  • W. Li, J. Wu, +4 authors H. Li
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 22 December 2014
Significance Notch signaling is known as a fundamental pathway that regulates the cell-fate determination in the inner ear. In present study, we show that Notch signaling also acts as a negativeExpand
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Identification of a Biomarker Profile Associated With Resistance to Neoadjuvant Chemoradiation Therapy in Rectal Cancer
Objective:To identify a biomarker profile associated with tumor response to chemoradiation (CRT) in locally advanced rectal cancer. Background:Rectal cancer response to neoadjuvant CRT is variable.Expand
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Phylogenetic analysis, structural evolution and functional divergence of the 12-oxo-phytodienoate acid reductase gene family in plants
BackgroundThe 12-oxo-phytodienoic acid reductases (OPRs) are enzymes that catalyze the reduction of double-bonds in α, β-unsaturated aldehydes or ketones and are part of the octadecanoid pathway thatExpand
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Distribution of Residual Cancer Cells in the Bowel Wall After Neoadjuvant Chemoradiation in Patients With Rectal Cancer
BACKGROUND: The standard treatment for locally advanced rectal cancer is preoperative cheimoradiation and total mesorectal excision. After surgery, tumors are classified according to the depth ofExpand
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Peroxynitrite-induced relaxation in isolated canine cerebral arteries and mechanisms of action.
The present study was undertaken to determine the vascular actions of peroxynitrite (ONOO(-)), the product of superoxide and nitric oxide (NO), in isolated canine cerebral arteries and to gainExpand
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Prostaglandin signaling regulates ciliogenesis by modulating intraflagellar transport
Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletelyExpand
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Peroxynitrite Induces Apoptosis in Rat Aortic Smooth Muscle Cells: Possible Relation to Vascular Diseases
An emerging body of evidence is accumulating to suggest that in vivo formation of free radicals in the vasculature, such as peroxynitrite (ONOO–), and programmed cell death (i.e., apoptosis) playExpand
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Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases
Chemoradiation is the treatment of choice for locally advanced head and neck squamous cell carcinoma (HNSCC). However, radioresistance, which contributes to local recurrence, remains a significantExpand
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The Effect of Layer-by-Layer Assembly Coating on the Proliferation and Differentiation of Neural Stem Cells.
  • W. Li, Teng Guan, +6 authors J. Kong
  • Materials Science, Medicine
  • ACS applied materials & interfaces
  • 3 February 2015
Nanocoating of a single-cell with biocompatible materials creates a defined microenvironment for cell differentiation and proliferation, as well as a model for studies in cell biology. In addition,Expand
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