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- Publications
- Influence
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
- D. Ehninger, S. Han, +5 authors A. Silva
- Medicine
- Nature Medicine
- 1 August 2008
Tuberous sclerosis is a single-gene disorder caused by heterozygous mutations in the TSC1 (9q34) or TSC2 (16p13.3) gene and is frequently associated with mental retardation, autism and epilepsy. Even… Expand
Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
- W. Li, Y. Zhou, +11 authors Tyrone D. Cannon
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 13 November 2007
Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14.3) that results in loss of the C terminus of the DISC1 protein, a region that is… Expand
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510… Expand
The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories
- B. Wiltgen, M. Zhou, +5 authors A. Silva
- Biology, Medicine
- Current Biology
- 10 August 2010
BACKGROUND
It is widely believed that the hippocampus plays a temporary role in the retrieval of episodic and contextual memories. Initial research indicated that damage to this structure produced… Expand
Transiogram: A spatial relationship measure for categorical data
- W. Li
- Computer Science
- Int. J. Geogr. Inf. Sci.
- 2006
TLDR
The HMG-CoA Reductase Inhibitor Lovastatin Reverses the Learning and Attention Deficits in a Mouse Model of Neurofibromatosis Type 1
Neurofibromatosis Type 1 (NF1) is a common neurological disorder caused by mutations in the gene encoding Neurofibromin, a p21Ras GTPase Activating Protein (GAP). Importantly, NF1 causes learning… Expand
Characterization of a Novel synGAP Isoform, synGAP-β*
We cloned a cDNA encoding a novel synGAP, synGAP-d (GenBankTM accession numberAB016962), from a rat brain cDNA library. The clone consisted of 4801 nucleotides with a coding sequence of 3501… Expand
Reversing Neurodevelopmental Disorders in Adults
- D. Ehninger, W. Li, K. Fox, M. Stryker, A. Silva
- Psychology, Medicine
- Neuron
- 26 December 2008
Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders.… Expand
The Absolute Magnitudes of Type Ia Supernovae in the Ultraviolet
- P. Brown, P. Roming, +19 authors D. V. Berk
- Physics
- 27 July 2010
We examine the absolute magnitudes and light-curve shapes of 14 nearby (redshift z = 0.004-0.027) Type Ia supernovae (SNe Ia) observed in the ultraviolet (UV) with the Swift Ultraviolet/Optical… Expand
Targeting AMPK for cancer prevention and treatment
- W. Li, Shakir M. Saud, M. R. Young, G. Chen, Baojin Hua
- Medicine
- Oncotarget
- 20 March 2015
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP… Expand