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Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Tuberous sclerosis is a single-gene disorder caused by heterozygous mutations in the TSC1 (9q34) or TSC2 (16p13.3) gene and is frequently associated with mental retardation, autism and epilepsy. EvenExpand
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Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice
Disrupted-in-schizophrenia 1 (DISC1) was initially discovered through a balanced translocation (1;11)(q42.1;q14.3) that results in loss of the C terminus of the DISC1 protein, a region that isExpand
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Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510Expand
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The Hippocampus Plays a Selective Role in the Retrieval of Detailed Contextual Memories
BACKGROUND It is widely believed that the hippocampus plays a temporary role in the retrieval of episodic and contextual memories. Initial research indicated that damage to this structure producedExpand
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Transiogram: A spatial relationship measure for categorical data
  • W. Li
  • Computer Science
  • Int. J. Geogr. Inf. Sci.
  • 2006
We propose a Markov chain-based geostatistics for simulating categorical variables. Expand
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The HMG-CoA Reductase Inhibitor Lovastatin Reverses the Learning and Attention Deficits in a Mouse Model of Neurofibromatosis Type 1
Neurofibromatosis Type 1 (NF1) is a common neurological disorder caused by mutations in the gene encoding Neurofibromin, a p21Ras GTPase Activating Protein (GAP). Importantly, NF1 causes learningExpand
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Characterization of a Novel synGAP Isoform, synGAP-β*
We cloned a cDNA encoding a novel synGAP, synGAP-d (GenBankTM accession numberAB016962), from a rat brain cDNA library. The clone consisted of 4801 nucleotides with a coding sequence of 3501Expand
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Reversing Neurodevelopmental Disorders in Adults
Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders.Expand
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The Absolute Magnitudes of Type Ia Supernovae in the Ultraviolet
We examine the absolute magnitudes and light-curve shapes of 14 nearby (redshift z = 0.004-0.027) Type Ia supernovae (SNe Ia) observed in the ultraviolet (UV) with the Swift Ultraviolet/OpticalExpand
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Targeting AMPK for cancer prevention and treatment
AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATPExpand
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