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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that, for… Expand
A generalized iterative LQG method for locally-optimal feedback control of constrained nonlinear stochastic systems
We present an iterative linear-quadratic-Gaussian method for locally-optimal feedback control of nonlinear stochastic systems subject to control constraints. Previously, similar methods have been… Expand
Tissue-Specific, Development-Dependent Phenolic Compounds Accumulation Profile and Gene Expression Pattern in Tea Plant [Camellia sinensis]
Phenolic compounds in tea plant [Camellia sinensis (L.)] play a crucial role in dominating tea flavor and possess a number of key pharmacological benefits on human health. The present research aimed… Expand
CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway.
BACKGROUND & AIMS Cancer cells exhibit the reprogrammed metabolism characterized by high level of glycolysis even in the presence of oxygen. Aerobic glycolysis, known as the Warburg effect, supplies… Expand
Control Techniques for LCL-Type Grid-Connected Inverters
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases.
- W. Li, J. Blankman, B. Cravatt
- Chemistry, Medicine
- Journal of the American Chemical Society
- 13 July 2007
Hydrolytic enzymes constitute one of the largest and most diverse protein classes in Nature and play key roles in nearly all physiological and pathological processes. The mammalian serine hydrolase… Expand
ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6/2 Mice
The serine hydrolase α/β-hydrolase domain 6 (ABHD6) hydrolyzes the most abundant endocannabinoid (eCB) in the brain, 2-arachidonoylglycerol (2-AG), and controls its availability at cannabinoid… Expand
High-Density Three-Dimension Graphene Macroscopic Objects for High-Capacity Removal of Heavy Metal Ions
The chemical vapor deposition (CVD) fabrication of high-density three-dimension graphene macroscopic objects (3D-GMOs) with a relatively low porosity has not yet been realized, although they are… Expand
Phase I trial of recombinant macrophage colony-stimulating factor and recombinant gamma-interferon: toxicity, monocytosis, and clinical effects.
Macrophage colony-stimulating factor (M-CSF) is a known inducer of proliferation and differentiation of cells of the mononuclear phagocyte lineage, and gamma-interferon (gamma-IFN) is a known… Expand
Comparison of coagulation behavior and floc structure characteristic of different polyferric-cationic polymer dual-coagulants in humic acid solution.
Three polyferric-cationic polymer dual-coagulants were comparatively evaluated in terms of coagulation behavior and floc structure characteristic in the coagulation of humic acid (HA) solution. The… Expand