• Publications
  • Influence
Mathematical model for studying genetic variation in terms of restriction endonucleases.
  • M. Nei, W. Li
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 October 1979
TLDR
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed and a measure called "nucleotide diversity" is proposed to express the degree of polymorphism in a population at the nucleotide level.
Statistical tests of neutrality of mutations.
TLDR
From these properties, several new statistical tests based on a random sample of DNA sequences from the population are developed for testing the hypothesis that all mutations at a locus are neutral.
The codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.
TLDR
A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed, useful for predicting the level of expression of a gene, for assessing the adaptation of viral genes to their hosts, and for making comparisons ofCodon usage in different organisms.
Rates of nucleotide substitution vary greatly among plant mitochondrial, chloroplast, and nuclear DNAs.
TLDR
The rate of cpDNA evolution appears to have slowed in some dicot lineages following the monocot/dicot split, and the slowdown is more conspicuous at nonsynonymous sites than at synonymous sites.
Genomic divergences between humans and other hominoids and the effective population size of the common ancestor of humans and chimpanzees.
TLDR
The human lineage apparently had experienced a large reduction in effective population size after its separation from the chimpanzee lineage, suggesting that the gorilla lineage branched off 1.6 to 2.2 million years earlier than did the human-chimpanzee divergence.
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes.
TLDR
The implication of the results for the mechanisms of DNA evolution and that of the relative likelihood of codon interchanges in parsimonious phylogenetic reconstruction are discussed.
Date of the monocot-dicot divergence estimated from chloroplast DNA sequence data.
TLDR
The results imply that the angiosperm lineage emerged in Jurassic-Triassic time, which considerably predates its appearance in the fossil record (approximately 120 Myr ago), which can be taken as an upper bound for the age of angiosperms.
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites.
TLDR
A maximum likelihood approach to estimating the variation of substitution rate among nucleotide sites according to an invariant+gamma distribution, which has two parameters: the gamma parameter alpha and the proportion of invariable sites theta.
Evidence for higher rates of nucleotide substitution in rodents than in man.
  • C. Wu, W. Li
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 March 1985
TLDR
It is found that rodents evolve significantly faster than man when the coding regions of 11 genes from rodents (mouse or rat) and man are compared with those from another mammalian species (usually bovine).
Low nucleotide diversity in man.
TLDR
The nucleotide diversity in humans is very low, probably due to a relatively small long-term effective population size rather than any severe bottleneck during human evolution.
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