Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
- R. Zajączkowska, M. Kocot-Kępska, W. Leppert, A. Wrzosek, J. Mika, J. Wordliczek
- MedicineInternational Journal of Molecular Sciences
- 1 March 2019
A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies and the neurotoxicity mechanisms of the most common antineoplastic agents are reviewed.
CYP2D6 in the Metabolism of Opioids for Mild to Moderate Pain
- W. Leppert
- Medicine, BiologyPharmacology
- 15 April 2011
Data is summarized on the impact of CYP2D6 polymorphism on pharmacokinetics, pharmacodynamics and adverse effects of weak opioids in patients with mild, moderate and in some cases strong pain intensity.
Tramadol as an analgesic for mild to moderate cancer pain.
- W. Leppert
- Medicine, BiologyPharmacological Reports
- 1 November 2009
The role of methadone in cancer pain treatment – a review
- W. Leppert
- Medicine, PsychologyInternational journal of clinical practice
- 1 July 2009
Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder and has potential to be a game-changer in the treatment of opioid addiction.
Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction
- W. Leppert
- Medicine, BiologyDrug Design, Development and Therapy
- 16 April 2015
A combination of prolonged-release oxycodone with prolonged-released naloxone (OXN) in one tablet provides analgesia with limited negative effect on the bowel function, as oxy codone displays high oral bioavailability and n aloxone demonstrates local antagonist effect on opioid receptors in the GI tract and is totally inactivated in the liver.
Treatment of nausea and vomiting in advanced cancer
- J. Łuczak, W. Leppert
- Medicine
- 3 October 2003
Nudnoœci i wymioty (N i W) nale¿1 do czêstych objawów, znacz1co obni¿aj1cych jakoœæ ¿ycia chorych na nowotwory i AIDS oraz z niewydolnoœci1 nerek i w1troby. Czêstoœæ wystêpowania N i W u chorych z…
The Role of Corticosteroids in the Treatment of Pain in Cancer Patients
- W. Leppert, T. Buss
- MedicineCurrent Pain and Headache Reports
- 29 May 2012
The use of corticosteroids in spinal cord compression, superior vena cava obstruction, raised intracranial pressure, and bowel obstruction is better established than in other nonspecific indications.
Transdermal and Topical Drug Administration in the Treatment of Pain
- W. Leppert, M. Malec-Milewska, R. Zajączkowska, J. Wordliczek
- Medicine, BiologyMolecules
- 1 March 2018
This review is aimed at presenting current knowledge on analgesics administered by transdermal and topical routes for physicians, nurses, pharmacists, and other health care professionals dealing with patients suffering from pain.
Bone Pain in Cancer Patients: Mechanisms and Current Treatment
- R. Zajączkowska, M. Kocot-Kępska, W. Leppert, J. Wordliczek
- MedicineInternational Journal of Molecular Sciences
- 30 November 2019
The mechanisms involved in the occurrence and persistence of cancer-associated bone pain are discussed and the treatment methods recommended by experts in clinical practice are reviewed to improve quality of life (QoL).
Oral Prolonged‐Release Oxycodone/Naloxone for Managing Pain and Opioid‐Induced Constipation: A Review of the Evidence
- B. Morlion, S. Mueller-Lissner, T. O'brien
- Medicine, BiologyPain Practice
- 1 June 2018
Fixed‐dose oxycodone/naloxone prolonged‐release tablets (OXN PR) were designed to address the opioid class effect of opioid‐induced constipation by combining the analgesic efficacy of oxyCodone with the opioid receptor antagonist, naloxon, which has negligible systemic availability when administered orally.
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