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CYP2D6 in the Metabolism of Opioids for Mild to Moderate Pain
In most cancer patients, pain is successfully treated with pharmacological measures using opioid analgesics for moderate to severe pain (strong opioids) alone or in combination with adjuvantExpand
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Tramadol as an analgesic for mild to moderate cancer pain.
  • W. Leppert
  • Medicine
  • Pharmacological reports : PR
  • 1 November 2009
In most cancer patients, pain is successfully treated with pharmacological measures such as opioid analgesics alone or opioid analgesics combined with adjuvant analgesics (co-analgesics). Opioids forExpand
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The role of methadone in cancer pain treatment – a review
  • W. Leppert
  • Medicine
  • International journal of clinical practice
  • 1 July 2009
Background:  Methadone is an opioid analgesic of step 3 of the World Health Organization (WHO) analgesic ladder.
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Treatment of nausea and vomiting in advanced cancer
Nudnoœci i wymioty (N i W) nale¿1 do czêstych objawów, znacz1co obni¿aj1cych jakoœæ ¿ycia chorych na nowotwory i AIDS oraz z niewydolnoœci1 nerek i w1troby. Czêstoœæ wystêpowania N i W u chorych zExpand
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  • PDF
Emerging therapies for patients with symptoms of opioid-induced bowel dysfunction
  • W. Leppert
  • Medicine
  • Drug design, development and therapy
  • 16 April 2015
Opioid-induced bowel dysfunction (OIBD) comprises gastrointestinal (GI) symptoms, including dry mouth, nausea, vomiting, gastric stasis, bloating, abdominal pain, and opioid-induced constipation,Expand
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Oral Prolonged‐Release Oxycodone/Naloxone for Managing Pain and Opioid‐Induced Constipation: A Review of the Evidence
Opioids provide effective relief from moderate‐to‐severe pain and should be prescribed as part of a multifaceted approach to pain management when other treatments have failed. Fixed‐doseExpand
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The role of tramadol in cancer pain treatment—a review
In most cancer patients pain can be successfully treated with pharmacological measures using opioid analgesics alone or in combination with adjuvant analgesics (coanalgesics). Weak opioids areExpand
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Tapentadol - A representative of a new class of MOR-NRI analgesics.
Tapentadol is a centrally acting analgesic with a dual mode of action as a μ-opioid receptor (MOR) agonist and a noradrenaline reuptake inhibitor (NRI). It was initially approved by the US Food andExpand
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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically, CIPN is a mostlyExpand
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The Role of Corticosteroids in the Treatment of Pain in Cancer Patients
Pain is one of the most frequent and most distressing symptoms in the course of cancer. The management of pain in cancer patients is based on the concept of the World Health Organization (WHO)Expand
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