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- Publications
- Influence
Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes.
- W. Leal
- Biology, Medicine
- Annual review of entomology
- 14 January 2013
Our knowledge of the molecular basis of odorant reception in insects has grown exponentially over the past decade. Odorant receptors (ORs) from moths, fruit flies, mosquitoes, and the honey bees have… Expand
Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex.
- B. Sandler, L. Nikonova, W. Leal, J. Clardy
- Biology, Medicine
- Chemistry & biology
- 1 February 2000
BACKGROUND
Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attract… Expand
Mosquitoes smell and avoid the insect repellent DEET
The insect repellent DEET is effective against a variety of medically important pests, but its mode of action still draws considerable debate. The widely accepted hypothesis that DEET interferes with… Expand
NMR structure reveals intramolecular regulation mechanism for pheromone binding and release
- R. K. Horst, F. Damberger, +5 authors K. Wüthrich
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 27 November 2001
Odorants are transmitted by small hydrophobic molecules that cross the aqueous sensillar lymph surrounding the dendrites of the olfactory neurons to stimulate the olfactory receptors. In insects, the… Expand
Rapid inactivation of a moth pheromone.
- Yuko Ishida, W. Leal
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 27 September 2005
We have isolated, cloned, and expressed a male antennae-specific pheromone-degrading enzyme (PDE) [Antheraea polyphemus PDE (ApolPDE), formerly known as Sensillar Esterase] from the wild silkmoth, A.… Expand
Conformational Change in the Pheromone-binding Protein fromBombyx mori Induced by pH and by Interaction with Membranes*
- H. Wojtasek, W. Leal
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 22 October 1999
The pheromone-binding protein (PBP) fromBombyx mori was expressed in Escherichia coliperiplasm. It specifically bound radiolabeled bombykol, the natural pheromone for this species. It appeared as a… Expand
The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism.
- M. Wogulis, T. Morgan, Yuko Ishida, W. Leal, D. K. Wilson
- Biology, Medicine
- Biochemical and biophysical research…
- 6 January 2006
The Anopheles gambiae mosquito is the main vector of malaria transmission in sub-Saharan Africa. We present here a 1.5A crystal structure of AgamOBP1, an odorant binding protein (OBP) from the A.… Expand
Multifunctional communication inRiptortus clavatus (Heteroptera: Alydidae): Conspecific nymphs and egg parasitoidOoencyrtus nezarae use the same adult attractant pheromone as chemical cue
- W. Leal, H. Higuchi, N. Mizutani, H. Nakamori, T. Kadosawa, Mikio Ono
- Biology, Medicine
- Journal of Chemical Ecology
- 1 July 1995
The bean bug,Riptortus clavatus lays scattered eggs (as opposed to the egg masses of pentatomids) on host as well as nonhost plants. Therefore, the first feeding stage (second-instar) nymphs emerging… Expand
Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone
- Y. Mao, Xianzhong Xu, +4 authors J. Clardy
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 18 October 2010
Culex mosquitoes introduce the pathogens responsible for filariasis, West Nile virus, St. Louis encephalitis, and other diseases into humans. Currently, traps baited with oviposition semiochemicals… Expand
Pheromone reception in fruit flies expressing a moth's odorant receptor
- Z. Syed, Y. Ishida, K. Taylor, D. Kimbrell, W. Leal
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 October 2006
We have expressed a male-specific, pheromone-sensitive odorant receptor (OR), BmorOR1, from the silkworm moth Bombyx mori in an “empty neuron” housed in the ab3 sensilla of a Drosophila Δhalo mutant.… Expand