• Publications
  • Influence
Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes.
  • W. Leal
  • Biology, Medicine
  • Annual review of entomology
  • 14 January 2013
Our knowledge of the molecular basis of odorant reception in insects has grown exponentially over the past decade. Odorant receptors (ORs) from moths, fruit flies, mosquitoes, and the honey bees haveExpand
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Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex.
BACKGROUND Insects use volatile organic molecules to communicate messages with remarkable sensitivity and specificity. In one of the most studied systems, female silkworm moths (Bombyx mori) attractExpand
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Mosquitoes smell and avoid the insect repellent DEET
  • Z. Syed, W. Leal
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 September 2008
The insect repellent DEET is effective against a variety of medically important pests, but its mode of action still draws considerable debate. The widely accepted hypothesis that DEET interferes withExpand
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NMR structure reveals intramolecular regulation mechanism for pheromone binding and release
Odorants are transmitted by small hydrophobic molecules that cross the aqueous sensillar lymph surrounding the dendrites of the olfactory neurons to stimulate the olfactory receptors. In insects, theExpand
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Rapid inactivation of a moth pheromone.
  • Yuko Ishida, W. Leal
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 27 September 2005
We have isolated, cloned, and expressed a male antennae-specific pheromone-degrading enzyme (PDE) [Antheraea polyphemus PDE (ApolPDE), formerly known as Sensillar Esterase] from the wild silkmoth, A.Expand
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Conformational Change in the Pheromone-binding Protein fromBombyx mori Induced by pH and by Interaction with Membranes*
The pheromone-binding protein (PBP) fromBombyx mori was expressed in Escherichia coliperiplasm. It specifically bound radiolabeled bombykol, the natural pheromone for this species. It appeared as aExpand
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The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism.
The Anopheles gambiae mosquito is the main vector of malaria transmission in sub-Saharan Africa. We present here a 1.5A crystal structure of AgamOBP1, an odorant binding protein (OBP) from the A.Expand
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Multifunctional communication inRiptortus clavatus (Heteroptera: Alydidae): Conspecific nymphs and egg parasitoidOoencyrtus nezarae use the same adult attractant pheromone as chemical cue
The bean bug,Riptortus clavatus lays scattered eggs (as opposed to the egg masses of pentatomids) on host as well as nonhost plants. Therefore, the first feeding stage (second-instar) nymphs emergingExpand
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Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone
Culex mosquitoes introduce the pathogens responsible for filariasis, West Nile virus, St. Louis encephalitis, and other diseases into humans. Currently, traps baited with oviposition semiochemicalsExpand
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Pheromone reception in fruit flies expressing a moth's odorant receptor
We have expressed a male-specific, pheromone-sensitive odorant receptor (OR), BmorOR1, from the silkworm moth Bombyx mori in an “empty neuron” housed in the ab3 sensilla of a Drosophila Δhalo mutant.Expand
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