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Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
Although the immediate receptors (immunophilins) of the immunosuppressants cyclosporin A (CsA) and FK506 are distinct, their similar mechanisms of inhibition of cell signaling suggest that their… Expand
Chemistry of condensed thiophenes. V. Sulfonation and sulfonyl bridging of m-terphenyl. Conversion to sulfonamides †
Reaction of m-terphenyl with 20% oleum at 100° gives both disulfonation and double sulfonyl bridging to yield benzothieno[2,3- b]dibenzothiophene-3,9-disulfonic acid 5,5,7,7-tetraoxide, isolated… Expand
hALK in complex with compound 9 (6-(((1S)-1-(5-Fluoropyridin-2-yl)ethyl)amino)-1-(3-methyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl)(morpholin-4-yl)methanone
hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine
Chemistry of Condensed Thiophenes. Part 5. Sulfonation and Sulfonyl Bridging of m‐Terphenyl. Conversion to Sulfonamides.