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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins.
A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares notable sequence similarity with a segment of the cellular Myc transforming protein, and may represent a characteristic property of a new category of DNA binding proteins. Expand
Isolation of a recombinant copy of the gene encoding C/EBP.
The isolation of a recombinant clone of the gene that encodes C/EBP yields a protein that binds in vitro to both the CCAAT homology and the enhancer core homology, providing conclusive evidence that a single gene product accounts for both binding activities. Expand
CCAAT/enhancer binding protein activates the promoter of the serum albumin gene in cultured hepatoma cells.
It is speculated that C/EBP may play a general role in establishing and maintaining the differentiated, nonproliferative state. Expand
The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite.
Experimental tests now provide support for the leucine zipper hypothesis, which predicts a new structural motif that plays a role in facilitating sequence-specific interaction between protein and DNA. Expand
Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.
The identification and purification of a nuclear protein from rat liver that binds selectively to DNA sequences associated with several animal virus enhancers is described, indicating that the initial interaction established between the 20-kD protein and each viral enhancer occurs via a common DNA sequence known as the enhancer core homology. Expand
Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.
Several lines of evidence indicate that the differentiation-induced nuclear factor is CCAAT/enhancer binding protein (C/EBP), a DNA-binding protein first isolated from rat liver. Expand
Tissue-specific expression, developmental regulation, and genetic mapping of the gene encoding CCAAT/enhancer binding protein.
Observations raise the possibility that the synthesis of C/EBP may be responsive to humoral factors and that modulation in C/ EBP expression might mediate coordinated changes in gene expression that facilitate adaptive challenges met during development or during the fluctuating physiological states of adult life. Expand
Efficacy of inhaled human insulin in type 1 diabetes mellitus: a randomised proof-of-concept study
This proof-of-concept study shows that preprandial insulin can be given by inhalation in individuals with insulin-deficient type 1 diabetes as a less invasive alternative to conventional prepr andial insulin injections. Expand
Monocarboxylate transporter expression in mouse brain.
Results suggest a differential expression of the two MCTs at the cellular level, with higher levels of hybridization in hippocampus and cerebellum and lower levels in lung, brain, and epididymal fat. Expand
In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.
We have used a recombinant bacteriophage that expresses the DNA-binding domain of C/EBP to optimize conditions for a screening technique that may facilitate the cloning of genes that encodeExpand