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Identification of a Neuronal Cdk5 Activator-binding Protein as Cdk5 Inhibitor*
TLDR
The Pho85·Pho80 kinase complex has been shown to be the yeast functional homologue of the mammalian Cdk5/p35 nck5a kinase, which is expressed primarily in neurons of central nervous tissue. Expand
Identification of a Common Protein Association Region in the Neuronal Cdk5 Activator*
TLDR
Several lines of evidence suggest that Nck5a interacts with the binding proteins at the hydrophilic face of the amphipathic α-helix, and substitution of Glu157 by glutamine abolishes the peptide's ability to bind to the three Nck 5a-binding proteins without diminishing its Cdk5 binding activity. Expand
A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor‐β and vascular endothelial growth factor signalling
TLDR
This study investigated the effects of largazole against liver fibrosis with a novel histone deacetylase (HDAC) inhibitor. Expand
The Significance of Microembolic Signals and New Cerebral Infarcts on the Progression of Neurological Deficit in Acute Stroke Patients with Large Artery Stenosis
TLDR
Investigation of the correlation between the progression of microembolic signal, ischemic infarcts and the neurological deficits in the acute phase of stroke patients with large artery occlusive disease found neither the disappearance of MES nor the changes in NIHSS score correlated with the progress of infarCT. Expand
Reversible Cerebral Vasoconstriction Syndrome with Posterior Leucoencephalopathy after Oral Contraceptive Pills
TLDR
A patient with angiographically confirmed RCVS whose MRI showed reversible brain oedema is reported, suggesting an overlap between RCVS and the reversible posterior leucoencephalopathy syndrome, supporting a role for female reproductive hormones in precipitating this overlap syndrome. Expand
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