• Publications
  • Influence
Identification of a Gene That Causes Primary Open Angle Glaucoma
Glaucoma is a major cause of blindness and is characterized by progressive degeneration of the optic nerve and is usually associated with elevated intraocular pressure. Analyses of sequence taggedExpand
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Clinical features associated with mutations in the chromosome 1 open-angle glaucoma gene (GLC1A)
BACKGROUND A substantial proportion of cases of glaucoma have a genetic basis. Mutations causing glaucoma have been identified in the chromosome 1 open-angle glaucoma gene (GLC1A), which encodes aExpand
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Axenfeld-Rieger syndrome in the age of molecular genetics.
  • W. L. Alward
  • Biology, Medicine
  • American journal of ophthalmology
  • 1 July 2000
PURPOSE To review the molecular genetics of Axenfeld-Rieger syndrome and related phenotypes and to discuss how this information might affect the way that we classify these disorders. METHODS AExpand
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A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome
Exfoliation syndrome (XFS) is the most common recognizable cause of open-angle glaucoma worldwide. To better understand the etiology of XFS, we conducted a genome-wide association study (GWAS) ofExpand
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Primary congenital and developmental glaucomas
Glaucoma is the leading cause of irreversible blindness worldwide. Although most glaucoma patients are elderly, congenital glaucoma and glaucomas of childhood are also important causes of visualExpand
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Medical management of glaucoma.
  • W. L. Alward
  • Medicine
  • The New England journal of medicine
  • 29 October 1998
Glaucoma is the leading cause of irreversible blindness in the world. It is estimated that by the year 2000, 66.8 million people will be affected, of whom 6.7 million will be blind in both eyes.1Expand
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Expression of the Mf1 gene in developing mouse hearts: Implication in the development of human congenital heart defects
The transcription factor FKHL7 gene has recently been associated with the anterior segment dysgenesis disorder of the eye known as Axenfeld‐Rieger anomaly (ARA). A growing body of evidence indicatesExpand
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Use of infrared videography to detect and record iris transillumination defects.
We have developed a technique of detecting and recording iris transillumination defects using an infrared sensitive video camera. This method is useful for assessing the loss of posterior irisExpand
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A New Angle on Ocular Development
Primary congenital glaucoma is a tragic blinding disease characterized by developmental defects in the meshwork that drains fluid from the eye resulting in an elevated intraocular pressure. In aExpand
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A history of gonioscopy.
  • W. L. Alward
  • Philosophy, Medicine
  • Optometry and vision science : official…
  • 2011
The first view of the iridocorneal angle in a living human occurred accidentally in the late 1800s. Lenses were first used to see the angle in 1914, but practical gonioscopy would not come intoExpand
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