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Ankyrin–1 mutations are a major cause of dominant and recessive hereditary spherocytosis
Hereditary spherocytosis (HS) is the most common inherited haemolytic anaemia in Northern Europeans. The primary molecular defects reside in the red blood cell (RBC) membrane, particularly inExpand
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Glucose-6-phosphate isomerase deficiency.
  • W. Kugler, M. Lakomek
  • Medicine, Biology
  • Bailliere's best practice & research. Clinical…
  • 1 March 2000
Most of the metabolic needs of erythrocytes are covered by glycolysis, the oxidative pentose phosphate pathway and the glutathione cycle. Hereditary enzyme deficiencies of all these pathways haveExpand
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  • Open Access
Endocrine status in elderly men with lower urinary tract symptoms: correlation of age, hormonal status, and lower urinary tract function. The Prostate Study Group of the Austrian Society of Urology.
OBJECTIVES To correlate endocrine parameters in elderly men with lower urinary tract symptoms (LUTS) to patient age and clinical parameters such as prostate volume, prostate-specific antigen (PSA)Expand
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Alkylglycerol opening of the blood–brain barrier to small and large fluorescence markers in normal and C6 glioma‐bearing rats and isolated rat brain capillaries
The blood–brain barrier (BBB) represents the major impediment to successful delivery of therapeutic agents to target tissue within the central nervous system. Intracarotid alkylglycerols have beenExpand
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  • Open Access
Molecular basis of recessive congenital methemoglobinemia, types I and II: Exon skipping and three novel missense mutations in the NADH‐cytochrome b5 reductase (diaphorase 1) gene
Hereditary methemoglobinemia due to reduced nicotin amide adenine dinucleotide (NADH)‐cytochrome b5 reductase (b5r) deficiency is classified into an erythrocyte type (I) and a generalized type (II).Expand
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Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine
Background: We have previously shown that the anti-neoplastic agent erucylphosphohomocholine (ErPC3) requires the mitochondrial 18 kDa Translocator protein (TSPO), formerly known as theExpand
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  • Open Access
Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma
Stanniocalcin 2 (STC2) is a secreted glycoprotein of as yet unknown functions. We investigated STC2 in human neuroblastoma, the most common solid extra‐cranial tumor of infancy. In primary tumorExpand
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Semaphorin-3D and Semaphorin-3E Inhibit the Development of Tumors from Glioblastoma Cells Implanted in the Cortex of the Brain
Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To determine if class-3 semaphorins can be usedExpand
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  • Open Access
Tumor localization of an anti-TGF-β antibody and its effects on gliomas.
Even with current standard-of-care therapies, the prognosis for patients with malignant gliomas is very poor and several new treatment modalities for glioblastomas are currently under investigation.Expand
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  • Open Access
Galectin-1 expression in human glioma cells: modulation by ionizing radiation and effects on tumor cell proliferation and migration.
Galectins are evolutionarily conserved beta-galactoside-binding lectins which recognize specific glycoconjugates on the cell surface and the extracellular matrix. Accumulating evidence indicates thatExpand
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  • Open Access