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Vascular endothelial growth factor is a secreted angiogenic mitogen.
TLDR
DNA sequencing suggests the existence of several molecular species of VEGF, a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo. Expand
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen
TLDR
Sequencing of cloned human apolipoprotein(a) complementary DMA shows that it is very similar to human plasminogen. Expand
Structure and functional expression of a human interleukin-8 receptor.
TLDR
The amino acid sequence shows that the IL-8 receptor is a member of the superfamily of receptors that couple to guanine nucleotide binding proteins (G proteins), which is 29% identical to that of receptors for the other neutrophil chemoattractants, fMet-Leu-Phe and C5a. Expand
Identification of Heregulin, a Specific Activator of p185erbB2
TLDR
Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family, and heregulin transcripts were identified in several normal tissues and cancer cell lines. Expand
Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
TLDR
The results suggest that p145c‐kit functions as a cell surface receptor for an as yet unidentified ligand, and carboxy‐ and amino‐terminal truncations that occurred during the viral transduction process are likely to have generated the transformation potential of v‐kit. Expand
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors
The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of theExpand
A fusion protein required for vesicle-mediated transport in both mammalian cells and yeast
TLDR
A protein sensitive toN-ethylmaleimide catalyses the fusion of transport vesicles with Golgi cisternae in a mammalian cell-free system and is equivalent to the SEC18 gene product of the yeast Saccharomyces cerevisiae, known to be essential for vesicle-mediated transport from the endoplasmic reticulum to the Golgi apparatus. Expand
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
TLDR
A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned and binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. Expand
Primary structure and mRNA localization of protein F1, a growth‐related protein kinase C substrate associated with synaptic plasticity.
TLDR
Co‐localization of protein F1 with protein kinase C‐II [PKC‐II (beta)], rather than PKC‐I (gamma) suggests thatPKC‐II may phosphorylate protein F 1, which can be detected at birth, and their level declines after maturation. Expand
Precursor structure, expression, and tissue distribution of human guanylin.
TLDR
Cl cloning and characterization of human and mouse cDNAs encoding precursor proteins of 115 and 116 amino acids, respectively, are described, demonstrating that guanylin is an endogenous activator of heat-stable enterotoxins known as STaR. Expand
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