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Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly.
Nitric oxide contrasts with most intercellular messengers because it diffuses rapidly and isotropically through most tissues with little reaction but cannot be transported through the vasculature dueExpand
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Otto Warburg's contributions to current concepts of cancer metabolism
Nature Reviews Cancer 11, 325–337 (2011) The acknowledgement for the source of Figure 1 on page 327 of this article was incorrect and has now been corrected online.
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Formation and properties of peroxynitrite as studied by laser flash photolysis, high-pressure stopped-flow technique, and pulse radiolysis.
Flash photolysis of alkaline peroxynitrite solutions results in the formation of nitrogen monoxide and superoxide. From the rate of recombination it is concluded that the rate constant of theExpand
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Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide.
Peroxynitrite [oxoperoxonitrate(1-), ONOO-] may be formed in vivo from superoxide and nitric oxide. The anion is stable, but the acid (pKa = 6.8) decays to nitrate with a rate of 1.3 s-1 at 25Expand
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The basic chemistry of nitrogen monoxide and peroxynitrite.
  • W. Koppenol
  • Medicine, Chemistry
  • Free radical biology & medicine
  • 1 September 1998
After a discussion of the physical chemistry of nitrogen monoxide, such as solubility (1.55 mM at 37 degrees C and an ionic strength of 0.15 M) and diffusion constant (4.8 x 10(-5) cm2s(-1)), severalExpand
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ALS, SOD and peroxynitrite
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Chemical Characterization of the Smallest S-Nitrosothiol, HSNO; Cellular Cross-talk of H2S and S-Nitrosothiols
Dihydrogen sulfide recently emerged as a biological signaling molecule with important physiological roles and significant pharmacological potential. Chemically plausible explanations for itsExpand
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The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress.
Production of minute concentrations of superoxide (O2(*-)) and nitrogen monoxide (nitric oxide, NO*) plays important roles in several aspects of cellular signaling and metabolic regulation. However,Expand
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The Haber-Weiss cycle – 70 years later
  • W. Koppenol
  • Chemistry, Medicine
  • Redox report : communications in free radical…
  • 1 August 2001
Abstract The chain reactions HO• + H2O2 → H2O + O2•- + H+ and O2•- + H+ + H2O2 → O2 + HO• + H2O, commonly known as the Haber-Weiss cycle, were first mentioned by Haber and Willst?tter in 1931. GeorgeExpand
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Electrode potentials of partially reduced oxygen species, from dioxygen to water.
We use published Gibbs energies of formation and equilibrium constants to determine electrode potentials for the partially reduced intermediates along the pathway of reduction of dioxygen to water,Expand
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