W. Koek

Publications281
h-index44
Citations6,319
Highly Influential Citations251
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WIN55,212‐2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine mouse model of Parkinson’s disease
TLDR
Data indicate that agonism at CB2 cannabinoid receptors protects against MPTP‐induced nigrostriatal degeneration by inhibiting microglial activation/infiltration and suggest that CB2 receptors represent a new therapeutic target to slow the degenerative process occurring in PD.
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Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice
TLDR
It is demonstrated that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which also transports 5-HT, is upregulated in the brains of mice with constitutively reduced5-HTT expression, and OCT3 may be an important transporter mediating serotonergic signaling when 5- HTT expression or function is compromised.
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Effect of early rearing conditions on alcohol drinking and 5-HT1A receptor function in C57BL/6J mice.
TLDR
There are long-term neurochemical consequences of social isolation of adolescent mice, specifically increased 5-HT1A receptor function in the dorsal raphe nucleus, which is suggested to be susceptible to the effects of post-weaning social isolation.
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Behavioral analyses of GHB: receptor mechanisms.
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Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
  • M. Kleven, W. Koek
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 March 1998
TLDR
Analysis of the relationship between behavioral and in vitro biochemical potencies indicated that inhibition of DA and 5-HT transport is responsible for the cocaine-enhancing effects of the monoamine reuptake blockers, and suggested that NE interactions may be relatively less important in the rat.
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Pharmacological characterization of in vivo properties of putative mixed 5-HT1A agonist/5-HT(2A/2C) antagonist anxiolytics. II. Drug discrimination and behavioral observation studies in rats.
TLDR
In vivo 5-HT1A agonist effects were demonstrated by the finding that relatively selective- and mixed-5-HT2A agonists produced one or more elements of the "serotonin syndrome," i.e., flat-body posture, forepaw treading, or lower-lip retraction, and produced high levels of drug-lever selection in rats trained to discriminate 8-OH-DPAT from saline.
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NMDA antagonists make learning and recall state-dependent.
TLDR
The data do not support the widely held notion that NMDA antagonists produce deficits in memory or retention; instead, at doses considerably lower than those impairing acquisition, NMda antagonists produce a state upon which the recall of the newly learned response is dependent.
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Differential effects of direct and indirect dopamine agonists on eye blink rate in cynomolgus monkeys.
  • M. Kleven, W. Koek
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 December 1996
TLDR
The results further characterize the involvement of DA receptors in the mediation of spontaneous eye blinks, reveal differential effects of direct and indirect agonists and suggest new directions for research into the neuroanatomical basis of DA-mediated spontaneous eye blinking.
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Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
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MK-801, a proposed noncompetitive antagonist of excitatory amino acid neurotransmission, produces phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys.
TLDR
The findings of this study offer further support for the hypothesis that certain behavioral effects of PCP-like drugs may result from a reduction of neurotransmission at excitatory synapses utilizing NMDA-preferring receptors.
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