Evidence for a causal association between human papillomavirus and a subset of head and neck cancers.
- M. Gillison, W. Koch, D. Sidransky
- Medicine, BiologyJournal of the National Cancer Institute
- 3 May 2000
It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1
- N. Agrawal, M. Frederick, J. Myers
- Medicine, BiologyScience
- 26 August 2011
To explore the genetic origins of head and neck squamous cell carcinoma, whole-exome sequencing and gene copy number analyses were used to study 32 primary tumors and identified mutations in FBXW7 and NotCH1, suggesting that NOTCH1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.
Case-control study of human papillomavirus and oropharyngeal cancer.
- G. D’Souza, A. Kreimer, M. Gillison
- MedicineNew England Journal of Medicine
- 10 May 2007
Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
TP53 mutations and survival in squamous-cell carcinoma of the head and neck.
- M. L. Poeta, J. Manola, W. Koch
- MedicineNew England Journal of Medicine
- 20 December 2007
Disruptive TP53 mutations in tumor DNA are associated with reduced survival after surgical treatment of squamous-cell carcinoma of the head and neck.
Poster 7: A Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization
- J. Califano, G. Clayman, R. Corio
- MedicineCancer Research
- 1 August 1996
Frequency of homozygous deletion at p16/CDKN2 in primary human tumours
- P. Cairns, T. Polascik, D. Sidransky
- Medicine, BiologyNature Genetics
- 1 October 1995
It is found that small homozygous deletions represent the predominant mechanism of inactivation at 9p21 in bladder tumours and are present in other tumour types, including breast and prostate cancer.
Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.
- M. Sanchez-Cespedes, M. Esteller, D. Sidransky
- Biology, MedicineCancer Research
- 15 February 2000
A statistically significant correlation between the presence of DAP-kinase gene promoter hypermethylation and lymph node involvement and advanced disease stage is detected and represents a promising serum marker for monitoring affected patients.
16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment
- R. Guerrero-Preston, F. Godoy-Vitorino, D. Sidransky
- Biology, MedicineOncoTarget
- 30 May 2016
Results suggest that microbiota may be used as HNSCC diagnostic and prognostic biomonitors and the relative abundance of OTU's within genus Streptococcus, Dialister, and Veillonella can be used to discriminate tumor from control samples.
Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission
- M. Loyo, R. Guerrero-Preston, D. Sidransky
- Medicine, BiologyInternational Journal of Cancer
- 15 June 2010
Results confirm that MCV is widespread in the human body and suggest a possible fecal‐oral transmission route similar to the Hepatitis A virus and appear that only neuroendocrine skin cells are susceptible to transformation by MCV.
Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck.
- J. Brennan, J. Boyle, D. Sidransky
- MedicineNew England Journal of Medicine
- 16 March 1995
A role for tobacco in the molecular progression of squamous-cell carcinoma of the head and neck and support the epidemiologic evidence that abstinence from smoking is important to preventHead and neck cancer are suggested.
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