W. Knöchel

Publications142
h-index35
Citations4,447
Highly Influential Citations255
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Five years on the wings of fork head
Since its discovery five years ago the conserved family of fork head/HNF-3-related transcription factors has gained increasing importance for the analysis of gene regulatory mechanisms during… Expand
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SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the… Expand
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Transcriptional regulation of BMP4 synexpression in transgenic Xenopus
Synexpression groups are genetic modules composed of genes that share both a complex expression pattern and the biological process in which they function. Here we investigate the regulation of BMP4… Expand
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Overexpression of the transcriptional repressor FoxD3 prevents neural crest formation in Xenopus embryos
Xenopus FoxD3 (XFD-6) is an intron-less gene initially expressed within the Spemann organizer and later in premigratory neural crest cells. Based upon sequence and expression pattern comparisons, it… Expand
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Axial patterning in snakes and caecilians: evidence for an alternative interpretation of the Hox code.
It is generally assumed that the characteristic deregionalized body plan of species with a snake-like morphology evolved through a corresponding homogenization of Hox gene expression domains along… Expand
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SHARP is a novel component of the Notch/RBP‐Jκ signalling pathway
Notch proteins are the receptors for an evolutionarily highly conserved signalling pathway that regulates numerous cell fate decisions during development. Signal transduction involves the… Expand
  • 218
  • 9
Bone morphogenetic protein 2 in the early development of Xenopus laevis
The temporal and spatial transcription patterns of the Xenopus laevis Bone morphogenetic protein 2 (BMP-2) gene have been investigated. Unlike the closely related BMP-4 gene, the BMP-2 gene is… Expand
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Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation
Three POU factors of subclass V, Oct-25, Oct-60 and Oct-91 are expressed in Xenopus oocytes and early embryos. We here demonstrate that vegetal overexpression of Oct-25, Oct-60, Oct-91 or mammalian… Expand
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Activin A induced expression of a fork head related gene in posterior chordamesoderm (notochord) of Xenopus laevis embryos.
A gene family encoding the fork head/HNF-3 domain has been identified in the South African clawed frog, Xenopus laevis. Screening of genomic DNA and gastrula stage derived cDNA libraries with a DNA… Expand
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The Drosophila fork head domain protein crocodile is required for the establishment of head structures.
The fork head (fkh) domain defines the DNA‐binding region of a family of transcription factors which has been implicated in regulating cell fate decisions across species lines. We have cloned and… Expand
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