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The regulation of quantal size
  • W. Kloot
  • Biology
  • Progress in Neurobiology
  • 1991
Quantal size can be altered experimentally by numerous treatments that seem to lack any common thread. The observations may seem haphazard and senseless unless clear distinctions are made from theExpand
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The kinetics of quantal releases during end-plate currents at the frog neuromuscular junction.
1. The preceding paper (Van der Kloot, 1988) described a method for estimating the timing of quantal releases during an end-plate current. This period of elevated quantal release is called the earlyExpand
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Estimating the timing of quantal releases during end-plate currents at the frog neuromuscular junction.
1. Following motor nerve stimulation there is a period of greatly enhanced quantal release, called the early release period or ERP (Barrett & Stevens, 1972b). Until now, measurements of theExpand
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Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased
We investigated whether the synaptic vesicles at the neuromuscular junction change size when their acetylcholine (ACh) content is altered. The size of the miniature endplate potential (MEPP)Expand
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  • PDF
The timing of channel opening during miniature end-plate currents
Many chemical transmitters act by opening channels with exponentially distributed life-times. We present a way to analyze a synaptic current in terms of its component channels. We can estimate theExpand
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The electrophysiology and the nervous control of the spiracular muscle of pupae of the giant silkmoths
Abstract 1. 1. The fibers of the spiracular closing muscle of the giant silk moths, Hyalophora cecropia and Telea polyphemeus , spontaneously generate action potentials and contract. 2. 2. TheExpand
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Recycling and refilling of transmitter quanta at the frog neuromuscular junction
Fluorescent dyes have been used at the frog neuromuscular junction to label synaptic vesicular membrane. Retrieved membrane is reformed into vesicles, which are released along with pre‐existingExpand
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Calcitonin gene‐related peptide acts presynaptically to increase quantal size and output at frog neuromuscular junctions
1 Calcitonin gene‐related peptide (CGRP) is found in dense‐cored vesicles in the motor nerve terminal. 2 Exogenous CGRP increased the size of the quanta. The increase in size reached a maximum afterExpand
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Nicotinic agonists antagonize quantal size increases and evoked release at frog neuromuscular junction.
1. Previous studies at the frog neuromuscular junction showed that quantal size can be increased two- to fourfold by a variety of treatments, including prior exposure to hypertonic solution (whichExpand
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Spontaneous and uniquantal‐evoked endplate currents in normal frogs are indistinguishable.
1. A recent paper concludes that the shapes of spontaneous and uniquantal-evoked signals are different. The signals were recorded with extracellular electrodes, often in the presence of neostigmine.Expand
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