• Publications
  • Influence
The regulation of quantal size
  • W. Kloot
  • Biology
    Progress in Neurobiology
  • 31 December 1991
At both frog and mouse NMJs quantal size is roughly doubled following exposure to hypertonic solutions, which supported the idea that quantal release rate is the signal for up regulation, and suggested that the signalfor up regulation is a period of greatly enhanced quantal output.
The kinetics of quantal releases during end-plate currents at the frog neuromuscular junction.
1. The preceding paper (Van der Kloot, 1988) described a method for estimating the timing of quantal releases during an end-plate current. This period of elevated quantal release is called the early
Estimating the timing of quantal releases during end-plate currents at the frog neuromuscular junction.
1. Following motor nerve stimulation there is a period of greatly enhanced quantal release, called the early release period or ERP (Barrett & Stevens, 1972b). Until now, measurements of the
Vesicle size and transmitter release at the frog neuromuscular junction when quantal acetylcholine content is increased or decreased
It is found that ACh content can change notably without any change in the size of the synaptic vesicles, and a hypertonic solution in which the anion was aspartate increased quantal size similar to gluconate.
The timing of channel opening during miniature end-plate currents
The results support the idea that some transmitter rebinds after dissociation from post-synaptic receptors, and suggest that the time of channel closing is related to the time at which acetylcholine leaves the receptor.
Lord Justice of Appeal John Fletcher Moulton and explosives production in World War I: ‘the mathematical mind triumphant’
At the end of November 1914 Lord Moulton (1844–1921) became the director of explosives production in the War Office. A 70-year-old jurist may seem an extraordinary choice, but he was an extraordinary
The electrophysiology and the nervous control of the spiracular muscle of pupae of the giant silkmoths
It is suggested that the ability to generate spontaneous activity, which is found only in the pupal insect, is an adaptation for life at low temperatures.
Tetanic stimulation increases the frequency of miniature end-plate potentials at the frog neuromuscular junction in Mn2+-, CO2+-, and Ni2+-saline solutions
It is concluded that Mn2+, Co2+, and Ni2+ can enter the nerve terminal through a voltage-gated channel and can stimulate quantal release by releasing Ca2+ or by causing the liberation of an activator, like H+, within the terminal.
Cocoon Construction By the Cecropia Silkworm I. the Role of the External Environment
It is concluded that the behavior patterns of the Cecropia silkworm are compounded of reflex-like responses to external stimuli and of "emitted" behavior independent of external stimulation.
Recycling and refilling of transmitter quanta at the frog neuromuscular junction
Recycling synaptic vesicles appear to be incorporated into the releasable pool from which they have roughly the same probability of release as the pre‐existing vesicle, as well as several other parameters used in calculating the fit.