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MicroRNA Expression in Zebrafish Embryonic Development
MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by miRNAs can play… Expand
The diverse functions of microRNAs in animal development and disease.
MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in detail. miRNAs have been… Expand
Genome-wide patterns and properties of de novo mutations in humans
Mutations create variation in the population, fuel evolution and cause genetic diseases. Current knowledge about de novo mutations is incomplete and mostly indirect. Here we analyze 11,020 de novo… Expand
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes
- W. Kloosterman, E. Wienholds, E. D. Bruijn, S. Kauppinen, R. H. A. Plasterk
- Medicine, Biology
- Nature Methods
MicroRNAs (miRNAs) are 20–23 nucleotide (nt) RNA molecules that regulate gene expression post-transcriptionally. A key step toward understanding the function of the hundreds of miRNAs identified in… Expand
Chromothripsis as a mechanism driving complex de novo structural rearrangements in the germline.
A variety of mutational mechanisms shape the dynamic architecture of human genomes and occasionally result in congenital defects and disease. Here, we used genome-wide long mate-pair sequencing to… Expand
Whole-genome sequence variation, population structure and demographic history of the Dutch population
Whole-genome sequencing enables complete characterization of genetic variation, but geographic clustering of rare alleles demands many diverse populations be studied. Here we describe the Genome of… Expand
From squiggle to basepair: computational approaches for improving nanopore sequencing read accuracy
Nanopore sequencing is a rapidly maturing technology delivering long reads in real time on a portable instrument at low cost. Not surprisingly, the community has rapidly taken up this new way of… Expand
Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development
- W. Kloosterman, A. Lagendijk, R. Ketting, J. D. Moulton, R. Plasterk
- Biology, Medicine
- PLoS biology
- 24 July 2007
Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as muscle differentiation, synapse function, and insulin secretion. In addition, analysis of Dicer null mutants… Expand
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system
- M. Kapsimali, W. Kloosterman, E. de Bruijn, F. Rosa, R. Plasterk, S. Wilson
- Biology, Medicine
- Genome Biology
- 21 August 2007
BackgroundMicroRNA (miRNA) encoding genes are abundant in vertebrate genomes but very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA targets and this information… Expand
Constitutional chromothripsis rearrangements involve clustered double-stranded DNA breaks and nonhomologous repair mechanisms.
Chromothripsis represents a novel phenomenon in the structural variation landscape of cancer genomes. Here, we analyze the genomes of ten patients with congenital disease who were preselected to… Expand