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Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB.
- B. Siedle, A. García-Piñeres, +7 authors I. Merfort
- Medicine, Chemistry
- Journal of medicinal chemistry
- 19 October 2004
This work investigates a set of 103 different sesquiterpene lactones representing 6 structural groups for their NF-kappaB inhibiting properties and the resulting IC(100)-values were submitted to a QSAR study. Expand
Sesquiterpene Lactones in a Hairy Root Culture of Cichorium intybus
- J. Malarz, Anna Stojakowska, W. Kisiel
- Chemistry, Medicine
- Zeitschrift fur Naturforschung. C, Journal of…
- 1 December 2002
A transformed root culture of Cichorium intybus L. (Asteraceae) was found to produce sesquiterpene lactones of guaiane and germacrane type and the yield of 8-desoxylactucin reached 0.03 g l-1 at the early stationary phase of the culture. Expand
Antifeedant properties and chemotaxonomic implications of sesquiterpene lactones and syringin from Rhaponticum pulchrum
In no-choice and two-choice feeding experiments aguerin B, chlorojanerin and syringin were shown to be good antifeedants against the three species of the stored product insect pests, while janer in and cynaropicrin inhibited feeding of the latter species. Expand
Effect of methyl jasmonate and salicylic acid on sesquiterpene lactone accumulation in hairy roots of Cichorium intybus
The effects of methyl jasmonate (MJ) or salicylic acid (SA) on the sesquiterpene lactone content and biomass accumulation were investigated in a hairy root culture of Cichorium intybus. The… Expand
Sesquiterpenoids and phenolics from Taraxacum hondoense.
Eleven sesquiterpene lactones, including the new guaianolide 11beta-hydroxydeacetylmatricarin-8-O-beta-glucopyranoside, along with four known phenolic glucosides were isolated from Taraxacum… Expand
Systematic implications of sesquiterpene lactones in Lactuca species
The results of the chemosystematic study of eleven species from the genus Lactuca (Asteraceae) support the status of the section Lactucin-type guaianolides, subsection Lactuba as a recognizable group within the genus, although Lactuce aculeata is a distinct species. Expand
Guaianolides from Cichorium intybus and Structure Revision of Cichorium Sesquiterpene Lactones
Salicylate and methyl jasmonate differentially influence diacetylene accumulation pattern in transformed roots of feverfew
In hairy root cultures of feverfew treated with methyl jasmonate, accumulation of spiroketal enol ether type diacetylenes of known deterrent activity was increased about two-fold and accumulation of the epoxide in clone M2 was more abundant. Expand
Hancokinol from Vincetoxicum officinale.
Hancokinol (1), a member of migrated lupane triterpenoids, was isolated from the aerial parts of Vincetoxicum officinale, along with known plant sterols and long chain alkanols.
Further sesquiterpenoids and phenolics from Taraxacum officinale.
Five germacrane- and guaiane-type sesquiterpene lactones, including two previously described taraxinic acid derivatives, were isolated from the roots of Taraxacum officinale, together with benzyl… Expand