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Muscarinic receptors: relationships among phosphoinositide breakdown, adenylate cyclase inhibition, in vitro detrusor muscle contractions and in vivo cystometrogram studies in guinea pig bladder.
The relationships between activation of muscarinic receptors in guinea pig bladder measured as carbachol-stimulated inositol phosphate (IP) accumulation, oxotremorine-induced adenylate cyclase (AC)Expand
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Characteristics and regulation of high affinity [3H]imipramine binding to rat hippocampal membranes
Abstract The imipramine binding sites located in the membrane of the rat hippocampus have been characterized in order to obtain a better understanding of their role in the treatment of mentalExpand
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Down regulation of dihydroalprenolol and imipramine binding sites in brain of rats repeatedly treated with imipramine.
In rats receiving repeated injections of imipramine, there is a reduction in the number of high affinity binding sites for [3H]imipramine and [3H]dihydroalprenolol present in crude synaptic membraneExpand
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Hippocampal distribution of acetylcholine, muscarinic receptors and cyclic GMP
Abstract The regional distribution of acetylcholine (ACh), guanosine 3′,5′-monophosphate (cyclic GMP), ACh fractional rate constant, ACh turnover rate and [3H]-quinuclidinyl benzilate (QNB) bindingExpand
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A biochemical study of receptor internalization during beta-adrenergic receptor desensitization in frog erythrocytes.
We have previously reported that in frog erythrocytes, a decrease in the number of β-adrenergic receptor recognition sites during subsensitivity of these receptors is associated with a translocationExpand
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Effects of some inhibitiors of cyclic nucleotide phosphodiesterase on protein phosphorylation in isolated neurons and glia from rat brain.
Summary The effects of the cyclic nucleotide phosphodiesterase inhibitors theophylline, 1-methyl-3-isobutylxanthine, and RO-20-1724 on protein phosphorylation in homogenates of isolated neurons andExpand
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Fluorescent derivatives of polyribonucleotides containing ε-adenosine
Abstract Polyriboadenylic acid may be converted to a fluorescent derivative by treatment with chloroacetaldehyde, which leads to the introduction of e-adenylate groups. The properties of suchExpand
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Pharmacological profile of adenosine A2 receptor in PC12 cells.
The PC12 cell line, a clone isolated from a pheochromocytoma tumor of rat adrenal medulla, was shown to exclusively contain stimulatory adenosine (A2) receptors linked to adenylate cyclase (AC). ACExpand
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The role of receptor binding in drug discovery.
Radioligand receptor binding has been used extensively to identify and characterize a host of receptors and enzymes targeting virtually every therapeutic area. Many drug discovery programs have beenExpand
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