W. Karl

Publications238
h-index21
Citations2,211
Highly Influential Citations62
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Scientific Cloud Computing: Early Definition and Experience
TLDR
Cloud computing emerges as a new computing paradigm which aims to provide reliable, customized and QoS guaranteed computing dynamic environments for end-users. Expand
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Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved.
Biotransformation of cerivastatin, a new cholesterol-lowering drug, by human liver microsomes was investigated using the 14C-labeled drug. Metabolite profiles were established by HPLC and structures… Expand
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What scientific applications can benefit from hardware transactional memory?
TLDR
Achieving efficient and correct synchronization of multiple threads is a difficult and error-prone task at small scale and, as we march towards extreme scale computing, will be even more challenging when the resulting application is supposed to utilize millions of cores efficiently. Expand
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Biotransformation of cerivastatin in mice, rats, and dogs in vivo.
Biotransformation of cerivastatin was investigated in mice, rats, and dogs in vivo using the 14C-labeled drug. Marked species differences exist, both in pathways and extent of cerivastatin… Expand
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Cache-Aware Multigrid Methods for Solving Poisson's Equation in Two Dimensions
TLDR
In this paper, we describe program transformation techniques developed to improve the cache performance of two-dimensional multigrid algorithms. Expand
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An Intuitive Framework for Accessing Computing Clouds
TLDR
This paper describes a generic framework implemented for Cloud users to access the various Cloud infrastructures in a unified fashion. Expand
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Metabolite proving fungal cleavage of the aromatic core part of a fluoroquinolone antibiotic
Liquid cultures of the basidiomycetous fungus Gloeophyllum striatum were employed to study the biodegradation of pradofloxacin, a new veterinary fluoroquinolone antibiotic carrying a CN group at… Expand
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Pharmacokinetics of nisoldipine. III. Biotransformation of nisoldipine in rat, dog, monkey, and man.
After intraduodenal administration of 14C-labelled (+/-) 3-isobutyl-5-methyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate (nisoldipine, Bay k 5552) to rats approx. 68% of the… Expand
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Biotransformation of nimodipine in rat, dog, and monkey.
14C-labelled (+/-) 3-isopropyl5-(2-methoxyethyl)1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl)-pyridine-3,5-dicarboxylate (nimodipine, Bay e 9736, Nimotop; CAS 66085-59-4) was administered orally to… Expand
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Biotransformation of nifedipine in rat and dog.
Following oral and/or intraduodenal administration, the biotransformation of 14C-labelled nifedipine (dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3, 5-dicarboxylate, Bay a 1040,… Expand
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