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Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury.
ABCB5 is a limbal stem cell gene required for corneal development and repair
It is shown that ATP-binding cassette, sub-family B, member 5 (ABCB5) marks LSCs and is required for LSC maintenance, corneal development and repair, and it is demonstrated that prospectively isolated human or murine ABCB5-positive L SCs possess the exclusive capacity to fully restore the cornea upon grafting to LSC-deficient mice in xenogeneic or syngeneic transplantation models.
Role of Lumican in the Corneal Epithelium during Wound Healing*
It is shown that injured mouse corneal epithelium ectopically and transiently expresses lumican during the early phase of wound healing, suggesting a potential lumican functionality unrelated to regulation of collagen fibrillogenesis, e.g. modulation of epithelial cell adhesion or migration.
Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium.
Endogenous TGFbeta enhances migration of corneal epithelium during wound healing in mice and the p38MAPK, but not the Smad, cascade plays a major role in promoting cell migration and in suppressing cell proliferation in migrating epithelia.
Transforming growth factor(beta)-mediated corneal myofibroblast differentiation requires actin and fibronectin assembly.
- J. Jester, J. Huang, P. Barry-Lane, W. Kao, W. Petroll, H. D. Cavanagh
- Biology, MedicineInvestigative ophthalmology & visual science
- 1 August 1999
The data suggest that TGFbeta-mediated alpha-SMA gene expression leading to myofibroblast transformation may involve an RGD-dependent phosphotyrosine signal transduction pathway.
Keratocan, a Cornea-specific Keratan Sulfate Proteoglycan, Is Regulated by Lumican*
It is demonstrated that lumican has a novel regulatory role in keratocan expression at the transcriptional level and this results help provide an explanation for the differences in severity of corneal manifestation found in Lum–/– and Kera-/– mice.
Roles of lumican and keratocan on corneal transparency
Experimental evidence indicates that lumican may have additional biological functions, such as modulation of cell migration and epithelium-mesenchyme transition in wound healing and tumorgenesis, besides regulating collagen fibrillogenesis.
Keratocan-deficient Mice Display Alterations in Corneal Structure*
- Chia-Yang Liu, D. Birk, J. Hassell, B. Kane, W. Kao
- BiologyJournal of Biological Chemistry
- 13 June 2003
Ablation of the Kera gene resulted in subtle structural alterations of collagenous matrix and did not perturb the expression of other SLRPs in cornea, showing that keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision.
Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling
TRPV1 receptors may play a role in mediating corneal epithelial inflammatory mediator secretion and subsequent hyperalgesia, and are suppressed by exposure to CPZ or MAPK inhibitors, or removal of Ca2+.
From Hair to Cornea: Toward the Therapeutic Use of Hair Follicle‐Derived Stem Cells in the Treatment of Limbal Stem Cell Deficiency
The therapeutic properties of using HFSC to treat LSCD in a mouse model while demonstrating a strong translational potential are highlighted and points to the niche as a key factor for determining stem cell differentiation.