W. Kannel

Publications729
h-index192
Citations169,533
Highly Influential Citations3,622
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General Cardiovascular Risk Profile for Use in Primary Care: The Framingham Heart Study
TLDR
A sex-specific multivariable risk factor algorithm can be conveniently used to assess general CVD risk and risk of individual CVD events (coronary, cerebrovascular, and peripheral arterial disease and heart failure) and can be used to quantify risk and to guide preventive care. Expand
Atrial fibrillation as an independent risk factor for stroke: the Framingham Study.
TLDR
The data suggest that the elderly are particularly vulnerable to stroke when atrial fibrillation is present, and the effects of hypertension, coronary heart disease, and cardiac failure on the risk of stroke became progressively weaker with increasing age. Expand
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study.
TLDR
The major potent lipid risk factor was HDL cholesterol, which had an inverse association with the incidence of coronary heart disease in either men or women and these associations were equally significant even when other lipids and other standard risk factors for coronaryHeart disease were taken into consideration. Expand
Obesity and the risk of heart failure.
TLDR
In this large, community-based sample, increased body-mass index was associated with an increased risk of heart failure and strategies to promote optimal body weight may reduce the population burden ofheart failure. Expand
Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: population-based estimates.
TLDR
High blood pressure, diabetes, and hypertension were significant independent predictors of AF, adjusting for age and other predisposing conditions, and echocardiographic features offer prognostic information for AF beyond the traditional clinical risk factors. Expand
Cardiovascular disease risk profiles.
TLDR
The equations demonstrated the potential importance of controlling multiple risk factors (blood pressure, total cholesterol, high-density lipoprotein cholesterol, smoking, glucose intolerance, and left ventricular hypertrophy) as opposed to focusing on one single risk factor. Expand
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.
TLDR
The estimation of left ventricular mass by echocardiography offers prognostic information beyond that provided by the evaluation of traditional cardiovascular risk factors, and it is concluded that an increase in left Ventricular mass predicts a higher incidence of clinical events, including death, attributable to cardiovascular disease. Expand
Epidemiologic features of chronic atrial fibrillation: the Framingham study.
TLDR
The development of chronic atrial fibrillation was associated with a doubling of overall mortality and of mortality from cardiovascular disease and among the risk factors for cardiovascular disease, diabetes and electrocardiographic evidence of left ventricular hypertrophy were related to the occurrence of atrialfibrillation. Expand
Overweight and obesity as determinants of cardiovascular risk: the Framingham experience.
TLDR
The overweight category is associated with increased relative and population attributable risk for hypertension and cardiovascular sequelae and interventions to reduce adiposity and avoid excess weight may have large effects on the development of risk factors and cardiovascular disease at an individual and population level. Expand
An updated coronary risk profile. A statement for health professionals.
Using a simple worksheet, a patient's 5- and 10-year CHD risks can be estimated. The components of the profile were selected because they are objective and strongly and independently related to CHD… Expand
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