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CD26/DPP4 - a potential biomarker and target for cancer therapy.
CD26/dipeptidyl peptidase (DPP)4 is a membrane-bound protein found in many cell types of the body, and a soluble form is present in body fluids. There is longstanding evidence that various primaryExpand
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Indications and results of completion pneumonectomy.
OBJECTIVES Completion pneumonectomy (CP) is widely known to be associated with a high morbidity and mortality. However, in certain instances, CP offers the only chance for a cure. The results of theExpand
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Dipeptidyl peptidase 4 as a therapeutic target in ischemia/reperfusion injury.
Dipeptidyl peptidase 4 (DPP4, DPPIV, CD26, EC was discovered more than four decades ago as a serine protease that cleaves off N-terminal dipeptides from peptide substrates. The developmentExpand
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Intragraft DPP IV inhibition attenuates post-transplant pulmonary ischemia/reperfusion injury after extended ischemia.
BACKGROUND CD26/DPP IV is a T-cell-membrane protein that cleaves dipeptides from extracellular peptides. Inhibition of its enzymatic activity using Pro-Pro-diphenylphosphonate derivatives has beenExpand
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Small animal models of experimental obliterative bronchiolitis.
Despite significant progress in the treatment of chronic lung allograft rejection, obliterative bronchiolitis (OB) remains the major limitation to long-term survival after lung transplantation. TheExpand
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Aberrant Lck Signal via CD28 Costimulation Augments Antigen-Specific Functionality and Tumor Control by Redirected T Cells with PD-1 Blockade in Humanized Mice
Purpose: Combination therapy of adoptively transferred redirected T cells and checkpoint inhibitors aims for higher response rates in tumors poorly responsive to immunotherapy like malignant pleuralExpand
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Inhibition of CD26/DPP IV attenuates ischemia/reperfusion injury in orthotopic mouse lung transplants: The pivotal role of vasoactive intestinal peptide
The T cell activation Ag CD26/dipeptidylpeptidase IV (DPP IV) combines co-stimulatory and enzymatic properties. Catalytically, it functions as an exopeptidase, modulating biological activity of keyExpand
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Successful lung transplantation after donor lung reconditioning with urokinase in ex vivo lung perfusion system.
Acute pulmonary embolism is considered a contraindication to lung donation for transplantation as it might result in graft dysfunction. Ex vivo lung perfusion (EVLP) is a novel method to assess andExpand
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Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia.
BACKGROUND N-Acetylcysteine (NAC), a thiol-containing compound that has been used as an anti-oxidant, may also lead to an increased glutathione synthesis. This study assessed the protective effect ofExpand
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Significance of total vascular exclusion for hepatic cryotherapy: an experimental study.
BACKGROUND In the liver, efficacy of cryosurgical ablation of tumors located near the retrohepatic vena cava is impaired by the heat-sink effect. This could be overcome by total vascular exclusionExpand
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