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hSK4, a member of a novel subfamily of calcium-activated potassium channels.
The gene for hSK4, a novel human small conductance calcium-activated potassium channel, or SK channel, has been identified and expressed in Chinese hamster ovary cells. In physiological saline hSK4Expand
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Slick (Slo2.1), a Rapidly-Gating Sodium-Activated Potassium Channel Inhibited by ATP
Neuronal stressors such as hypoxia and firing of action potentials at very high frequencies cause intracellular Na+ to rise and ATP to be consumed faster than it can be regenerated. We report theExpand
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Sleep in Drosophila is regulated by adult mushroom bodies
Sleep is one of the few major whole-organ phenomena for which no function and no underlying mechanism have been conclusively demonstrated. Sleep could result from global changes in the brain duringExpand
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Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel
We describe here a general technique for the graded inhibition of cellular excitability in vivo. Inhibition is accomplished by expressing a genetically modified Shaker K(+) channel (termed the EKOExpand
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Identification of SLEEPLESS, a Sleep-Promoting Factor
Sleep is an essential process conserved from flies to humans. The importance of sleep is underscored by its tight homeostatic control. Through a forward genetic screen, we identified a gene,Expand
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A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A
BACKGROUND Although sleep is an important process essential for life, its regulation is poorly understood. The recently developed Drosophila model for sleep provides a powerful system to geneticallyExpand
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Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Large-conductance calcium-activated potassium channels (maxi-K channels) have an essential role in the control of excitability and secretion. Only one gene Slo is known to encode maxi-K channels,Expand
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A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem
POTASSIUM channels catalyse the permeation of K+ ions across cellular membranes and are identified by a common structural motif, a highly conserved signature sequence of eight amino acids in the PExpand
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hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes
Human T lymphocytes express a Ca2+-activated K+ current (IK), whose roles and regulation are poorly understood. We amplified hSK4 cDNA from human T lymphoblasts, and we showed that its biophysicalExpand
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A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia
One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to study these transitions.Expand
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