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Host-Gut Microbiota Metabolic Interactions
TLDR
A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
Serum metabolite profiling of human colorectal cancer using GC-TOFMS and UPLC-QTOFMS.
  • Y. Qiu, G. Cai, +8 authors W. Jia
  • Chemistry, Medicine
    Journal of proteome research
  • 4 September 2009
Colorectal carcinogenesis involves the overexpression of many immediate-early response genes associated with growth and inflammation, which significantly alters downstream protein synthesis and
Serum and Urine Metabolite Profiling Reveals Potential Biomarkers of Human Hepatocellular Carcinoma*
TLDR
This work shows that metabolomic profiling approach is a promising screening tool for the diagnosis and stratification of HCC patients with alpha fetoprotein values lower than 20 ng/ml with an accuracy of 100% using a panel of metabolite markers.
Supplementation of Milled Chia Seeds Increases Plasma ALA and EPA in Postmenopausal Women
TLDR
In conclusion, ingestion of 25 g/day milled chia seeds for seven weeks by postmenopausal women resulted in significant increases in plasma ALA and EPA but not DPA and DHA.
Urinary metabonomic study on colorectal cancer.
  • Y. Qiu, G. Cai, +8 authors W. Jia
  • Chemistry, Medicine
    Journal of proteome research
  • 17 February 2010
TLDR
This study assessed the important metabonomic variations in urine associated with CRC and provided baseline information complementary to serum/plasma and tissue metabonomics for the complete elucidation of the underlying metabolic mechanisms of CRC.
Distinct urinary metabolic profile of human colorectal cancer.
TLDR
These findings confirm distinct urinary metabolic footprints of CRC patients characterized by altered levels of metabolites derived from gut microbial-host co-metabolism and provide a novel and promising molecular diagnostic approach for the early detection of CRC.
Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
  • W. Jia, G. Xie, W. Jia
  • Biology, Medicine
    Nature Reviews Gastroenterology & Hepatology
  • 1 February 2018
TLDR
The mechanistic links between bile acids and gastrointestinal carcinogenesis in CRC and HCC are discussed, which involve two major bile acid-sensing receptors, farnesoid X receptor (FXR) and G protein-coupled bile Acid receptor 1 (TGR5).
Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research.
In this study, metabolite profiling of five medicinal Panax herbs including Panax ginseng (Chinese ginseng), Panax notoginseng (Sanchi), Panax japonicus (Rhizoma Panacis Majoris), Panax quinquefolium
Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.
TLDR
It is suggested that quercetin is equally or more effective than trans-RSV in attenuating TNF-α-mediated inflammation and insulin resistance in primary human adipocytes.
Salivary metabolite signatures of oral cancer and leukoplakia
TLDR
The utility of salivary metabolome diagnostics for oral cancer is successfully demonstrated and results suggest that metabolomics approach complements the clinical detection of OSCC and stratifies the two types of lesions, leading to an improved disease diagnosis and prognosis.
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