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Hedgehog signalling controls eye degeneration in blind cavefish
TLDR
It is shown that sonic hedgehog and tiggy-winkle hedgehog gene expression is expanded along the anterior embryonic midline in several different cavefish populations, supporting the role of hh signalling in the evolution of cavefish eye regression. Expand
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
TLDR
The generation of a genome-wide linkage map is described to allow quantitative trait analysis of evolutionarily derived morphologies in the Mexican cave tetra, a species that has, in a series of independent caves, repeatedly evolved specialized characteristics adapted to a unique and well-studied ecological environment. Expand
Adaptive evolution of eye degeneration in the Mexican blind cavefish.
  • W. Jeffery
  • Biology, Medicine
  • The Journal of heredity
  • 1 May 2005
TLDR
It is concluded that eye degeneration in cavefish may be caused by adaptive evolution and pleiotropy, and a key discovery is that Hedgehog midline signaling is expanded and inhibits eye formation by inducing lens apoptosis in Cavefish embryos. Expand
Cavefish as a model system in evolutionary developmental biology.
  • W. Jeffery
  • Biology, Medicine
  • Developmental biology
  • 1 March 2001
TLDR
Genetic analysis indicates that multiple genes regulate eye degeneration, and molecular studies suggest that Pax6 may be one of the genes controlling cavefish eye degenerations, and further studies of the Astyanax system will contribute to the understanding of the evolution of developmental mechanisms in vertebrates. Expand
Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish
TLDR
It is suggested that cryptic variation played a role in the evolution of eye loss in cavefish and the first evidence for HSP90 as a capacitor for morphological evolution in a natural setting is provided. Expand
Evolution of a Behavioral Shift Mediated by Superficial Neuromasts Helps Cavefish Find Food in Darkness
TLDR
It is concluded that VAB and SN enhancement coevolved to compensate for loss of vision and to help blind cavefish find food in darkness. Expand
Evidence for multiple genetic forms with similar eyeless phenotypes in the blind cavefish, Astyanax mexicanus.
TLDR
An analysis of variation in the mitochondrial NADH dehydrogenase 2 (ND2) gene among different surface fish and cavefish populations identifies a minimum of two genetically distinctive cavefish lineages with similar eyeless phenotypes. Expand
Development and evolution of craniofacial patterning is mediated by eye‐dependent and ‐independent processes in the cavefish Astyanax
TLDR
The results suggest that evolution of the cavefish craniofacial skeleton is controlled by multiple developmental events, some a direct consequence of eye degeneration and others unrelated to loss of the eye. Expand
Trunk lateral cells are neural crest-like cells in the ascidian Ciona intestinalis: insights into the ancestry and evolution of the neural crest.
TLDR
The results suggest that NCLC and neural crest cells may be homologous cell types originating in the common ancestor of tunicates and vertebrates and support the possibility that a putative regulatory network governing NCLCs development was co-opted to produce Neural crest cells during vertebrate evolution. Expand
Migratory neural crest-like cells form body pigmentation in a urochordate embryo
TLDR
A hypothesis for neural crest evolution beginning with the release of migratory cells from the CNS to produce body pigmentation in the common ancestor of the urochordates and vertebrates is proposed. Expand
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