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A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation
Background There is evidence suggesting that sirolimus, in combination with tacrolimus, is active in the prevention of graft-versus-host disease. Sirolimus-based immune suppression may suppress… Expand
INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect
- A. Chiappori, H. Soliman, W. Janssen, S. Antonia, D. Gabrilovich
- Expert opinion on biological therapy
- 6 May 2010
Importance of the field: Novel approaches are needed for patients with small cell lung cancer (SCLC), as response after relapse is poor with standard therapies. p53 gene mutations often occur,… Expand
Sirolimus for treatment of steroid-refractory acute graft-versus-host disease
Acute GVHD (aGVHD) is a major cause of morbidity and mortality in hematopoietic allograft recipients. The best therapy for patients failing to respond, or not tolerating, systemic glucocorticoids… Expand
Cell therapy medical tourism: time for action.
1 Department of Research and Development, Hospira Inc., Lake Forest, Illinois, USA, 2 Department of Medical Ethics, University of Pennsylvania, Philadelphia, Pennsylvania, USA, 3 Advanced Centre for… Expand
5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation
Relapse remains a leading cause for treatment failure after hematopoietic cell transplantation (HCT) in patients with intermediate- or high-risk myelodysplastic syndrome (MDS). To discern the impact… Expand
Mobilized peripheral blood SSCloALDHbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous…
- P. Fallon, T. Gentry, +5 authors Clay Smith
- Biology, Medicine
- British journal of haematology
- 1 July 2003
Summary. We have developed an approach for identifying primitive mobilized peripheral blood cells (PBSC) that express high levels of aldehyde dehydrogenase (ALDH). PBSC were stained with a… Expand
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.
- S. Finkelstein, C. Iclozan, +15 authors D. Gabrilovich
- International journal of radiation oncology…
- 1 February 2012
PURPOSE The goal of this study was to determine the effect of combination of intratumoral administration of dendritic cells (DC) and fractionated external beam radiation (EBRT) on tumor-specific… Expand
An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP kinase-dependent, NF-kappaB-independent mechanism.
Treatment of U937 cells with an IkappaBalpha phosphorylation inhibitor, Bay 11-7085, induced a rapid phosphorylation of p38 mitogen-activated protein (MAP) kinase, significant apoptosis, extensive… Expand
Clinical significance of bone marrow metastases as detected using the polymerase chain reaction in patients with breast cancer undergoing high-dose chemotherapy and autologous bone marrow…
- K. Fields, G. Elfenbein, W. Trudeau, J. Perkins, W. Janssen, L. Moscinski
- Journal of clinical oncology : official journal…
- 1 June 1996
PURPOSE The present study evaluates the clinical significance of detection of cytokeratin 19 (K19) in the bone marrow of patients with breast cancer undergoing high-dose chemotherapy (HDCT) and… Expand
The CD34+ cell fraction in bone marrow and blood is not universally predictive of CFU-GM.
- W. Janssen, M. J. Farmelo, C. Lee, R. Smilee, L. Kronish, G. Elfenbein
- Biology, Medicine
- Experimental hematology
- 1 May 1992
We have measured the presence of granulocyte-macrophage colony forming cells (CFU-GM) and CD34+ cells in blood and bone marrow. We have compared these hematopoietic cell assays using regression… Expand