A randomized phase II study to evaluate tacrolimus in combination with sirolimus or methotrexate after allogeneic hematopoietic cell transplantation
- J. Pidala, Jongphil Kim, C. Anasetti
- Medicine, BiologyHaematologica
- 11 June 2012
It is demonstrated that sirolimus/tacrolimus prevents grade II-IV acute graft-versus-host disease and moderate-severe chronic graft-version disease more effectively and supports regulatory T-cell reconstitution following allogeneic hematopoietic cell transplantation.
Lentiviral Gene Therapy Combined with Low‐Dose Busulfan in Infants with SCID‐X1
- E. Mamcarz, Sheng Zhou, B. Sorrentino
- Medicine, BiologyNew England Journal of Medicine
- 17 April 2019
Lentiviral vector gene therapy combined with low‐exposure, targeted busulfan conditioning in infants with newly diagnosed SCID‐X1 had low‐grade acute toxic effects and resulted in multilineage engraftment of transduced cells, reconstitution of functional T cells and B cells, and normalization of NK‐cell counts during a median follow‐up of 16 months.
INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect
- A. Chiappori, H. Soliman, W. Janssen, S. Antonia, D. Gabrilovich
- Medicine, BiologyExpert Opinion on Biological Therapy
- 6 May 2010
The characteristics and manufacturing of INGN-225, a p53-modified adenovirus-tranduced dendritic cell vaccine, are described, and a significant immune response is induced, which appears to sensitize SCLC to subsequent chemotherapy.
Sirolimus for treatment of steroid-refractory acute graft-versus-host disease
- D. Hoda, J. Pidala, M. Kharfan-Dabaja
- Medicine, BiologyBone Marrow Transplantation
- 1 August 2010
Sirolimus is effective in controlling steroid-refractory aGVHD and achieves CR, defined as complete resolution of aGV HD sustained for at least 1 month, after sirolimu initiation without additional immunosuppressive agents.
Clinical significance of bone marrow metastases as detected using the polymerase chain reaction in patients with breast cancer undergoing high-dose chemotherapy and autologous bone marrow…
- K. Fields, G. Elfenbein, W. Trudeau, J. Perkins, W. Janssen, L. Moscinski
- Medicine, BiologyJournal of Clinical Oncology
- 1 June 1996
It has been shown that PCR is a highly sensitive method to detect K19 message in the bone marrow and the presence of K19 is associated with a poor prognosis in patients with breast cancer undergoing high-dose chemotherapy and ABMT.
5-Azacitidine for myelodysplasia before allogeneic hematopoietic cell transplantation
- T. Field, J. Perkins, C. Anasetti
- Medicine, BiologyBone Marrow Transplantation
- 1 February 2010
Analysis of post transplant outcomes of 54 consecutive patients with MDS or chronic myelomonocytic leukemia who received HCT from HLA-compatible donors according to pretransplant 5-azacitidine exposure suggests that outcomes are similar in both groups with a trend toward decreased early relapse in patients receiving 5-azerpine.
Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients.
- S. Finkelstein, C. Iclozan, D. Gabrilovich
- Medicine, BiologyInternational Journal of Radiation Oncology…
- 1 February 2012
Cell therapy medical tourism: time for action.
- K. Gunter, A. Caplan, E. Horwitz
- 1 December 2010
This dissertation aims to provide a history of bone marrow transplantation in the United States and some examples of successful transplants over a 25-year period showed marked improvements in the quality and quantity of transplanted bone marrow.
A Pilot Trial of Humanized Anti-GD2 Monoclonal Antibody (hu14.18K322A) with Chemotherapy and Natural Killer Cells in Children with Recurrent/Refractory Neuroblastoma
- Sara M. Federico, M. B. McCarville, W. Furman
- Medicine, BiologyClinical Cancer Research
- 21 September 2017
A fixed dose of a unique anti-GD2 mAb, hu14.18K322A, combined with chemotherapy, cytokines, and haploidentical natural killer cells is feasible and resulted in clinically meaningful responses in patients with refractory/recurrent neuroblastoma.
Mobilized peripheral blood SSCloALDHbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous…
- P. Fallon, T. Gentry, Clay A. Smith
- Medicine, BiologyBritish Journal of Haematology
- 1 July 2003
Summary. We have developed an approach for identifying primitive mobilized peripheral blood cells (PBSC) that express high levels of aldehyde dehydrogenase (ALDH). PBSC were stained with a…