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New use of BCG for recombinant vaccines
Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed and can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Results suggest that InhA is likely a primary target of action for INH and ETH and that it may be involved in mycolic acid biosynthesis.
Whole-Genome Comparison of Mycobacterium tuberculosis Clinical and Laboratory Strains
Results demonstrate that polymorphisms among M. tuberculosis strains are more extensive than initially anticipated, and genetic variation may have an important role in disease pathogenesis and immunity.
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
It is reported that persistence of M. tuberculosis in mice is facilitated by isocitrate lyase (ICL), an enzyme essential for the metabolism of fatty acids, an observation with important implications for the treatment of chronic tuberculosis.
The primary mechanism of attenuation of bacillus Calmette–Guérin is a loss of secreted lytic function required for invasion of lung interstitial tissue
- Tsungda Hsu, S. Hingley-Wilson, W. Jacobs
- Biology, MedicineProceedings of the National Academy of Sciences…
- 13 October 2003
The primary attenuating mechanism of bacillus Calmette–Guérin is the loss of cytolytic activity mediated by secreted ESAT-6, which results in reduced tissue invasiveness.
Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice
Using signature-tagged mutagenesis, three attenuated M. tuberculosis mutants are isolated that cannot synthesize or transport a complex, cell wall-associated lipid called phthiocerol dimycocerosate (PDIM) which is found only in pathogenic mycobacteria.
Origins of Highly Mosaic Mycobacteriophage Genomes
The Alternative Sigma Factor SigH Regulates Major Components of Oxidative and Heat Stress Responses in Mycobacterium tuberculosis
- Sahadevan Raman, T. Song, X. Puyang, S. Bardarov, W. Jacobs, R. Husson
- BiologyJournal of bacteriology
- 15 October 2001
It is determined that a M. tuberculosis sigH mutant is more susceptible to oxidative stresses and that the inducible expression of the thioredoxin reductase/thiOREDoxin genes trxB2/trxC and a gene of unknown function is regulated by sigH via expression from promoters directly recognized by SigH.
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
- D. A. Rozwarski, G. A. Grant, D. H. Barton, W. Jacobs, J. Sacchettini
- Biology, ChemistryScience
- 2 January 1998
Data from x-ray crystallography and mass spectrometry reveal that the mechanism of isoniazid action against InhA is covalent attachment of the activated form of the drug to the Nicotinamide ring of nicotinamide adenine dinucleotide bound within the active site of Inh A.
The emb operon, a gene cluster of Mycobacterium tuberculosis involved in resistance to ethambutol
This work used resistance to EMB as a tool to identify genes participating in the biosynthesis of the mycobacterial cell wall and led to the identification of the embCAB gene cluster, recently proposed to encode for myc Cobacterium tuberculosis arabinosyl transferases.